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Gene

SRPK3

SRSF protein kinase 3

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 153,781,041–153,785,730 (GRCh38)
Exons
15 exons across 4.7 kb
Protein
567 amino acids
Also known as
MSSK1
Previous symbols
STK23
MANE Select transcript
ENST00000370101.8NM_014370.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How SRPK3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome X, with a bracket where SRPK3 sits. SRPK3 and 33 genes near it on chromosome X, from 153,283,386 to 154,283,385.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28153.4 Mb153.6 Mb153.8 Mb154 Mb154.2 MbPNMA6F: 153,317,680–153,321,774, reverse strandPNMA6FZNF275: 153,334,122–153,360,110, forward strandZNF275PNMA6E: 153,395,639–153,401,392, reverse strandPNMA6EZFP92: 153,411,434–153,426,481, forward strandZFP92TREX2: 153,444,473–153,470,592, reverse strandTREX2HAUS7: 153,447,655–153,495,529, reverse strandHAUS7BGN: 153,488,654–153,510,711, forward strandBGNATP2B3: 153,517,620–153,582,939, forward strandATP2B3CCNQ: 153,587,925–153,600,045, reverse strandCCNQDUSP9: 153,642,397–153,651,326, forward strandDUSP9PNCK: 153,669,730–153,689,033, reverse strandPNCKSLC6A8: 153,687,914–153,696,591, forward strandSLC6A8BCAP31: 153,698,006–153,725,957, reverse strandBCAP31ABCD1: 153,724,495–153,744,755, forward strandABCD1PLXNB3: 153,764,179–153,779,346, forward strandPLXNB3SRPK3: 153,781,041–153,785,730, forward strandSRPK3IDH3G: 153,785,735–153,794,535, reverse strandIDH3GSSR4: 153,793,516–153,798,510, forward strandSSR4PDZD4: 153,802,161–153,830,935, reverse strandL1CAM: 153,861,511–153,886,204, reverse strandL1CAM: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,367–153,934,999, reverse strandARHGAP4NAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandIRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28Diagram of SRPK3: 15 exons on the forward strand of chromosome XExon 3: 1 known disease-causing siteExon 1: 153,781,041–153,781,145, 105 basesExon 2: 153,781,216–153,781,346, 131 basesExon 3: 153,781,505–153,781,613, 109 basesExon 4: 153,781,743–153,781,830, 88 basesExon 5: 153,782,121–153,782,208, 88 basesExon 6: 153,782,772–153,782,878, 107 basesExon 7: 153,782,953–153,783,118, 166 basesExon 8: 153,783,226–153,783,251, 26 basesExon 9: 153,783,752–153,783,884, 133 basesExon 10: 153,783,974–153,784,213, 240 basesExon 11: 153,784,294–153,784,394, 101 basesExon 12: 153,784,750–153,784,857, 108 basesExon 13: 153,784,934–153,785,003, 70 basesExon 14: 153,785,081–153,785,173, 93 basesExon 15: 153,785,336–153,785,730, 395 bases1234567891011121314155′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2 kb of the gene's 4.7 kb; 1,704 of those bases code for the protein.

    How a genome test reads SRPK3

    1

    position in SRPK3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 4.7 kb of SRPK3, introns included, not only the 2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SRPK3 gene: SRSF protein kinase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/srpk3

    Vancouver

    Dante Labs. SRPK3 gene: SRSF protein kinase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/srpk3

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