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Gene

ADCY5

adenylate cyclase 5

Summary

Cytogenetic location
3q21.1
Coordinates
Chromosome 3: 123,282,296–123,449,090 (GRCh38)
Exons
21 exons across 166.8 kb
Protein
1,261 amino acids
Also known as
AC5
MANE Select transcript
ENST00000462833.6NM_183357.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ADCY5 yet. The test sequences your whole genome, so your data includes it all the same.

How ADCY5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where ADCY5 sits. ADCY5 and 6 genes near it on chromosome 3, from 122,865,693 to 123,865,692.Chromosome 33q21.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29123 Mb123.2 Mb123.4 Mb123.6 Mb123.8 MbSLC49A4: 122,794,819–122,881,144, forward strandSLC49A4SEMA5B: 122,908,722–123,028,605, reverse strandSEMA5BPDIA5: 123,067,017–123,225,227, forward strandPDIA5SEC22A: 123,201,859–123,275,509, forward strandSEC22AADCY5: 123,282,296–123,449,090, reverse strandADCY5HACD2: 123,490,820–123,585,193, reverse strandHACD2MYLK: 123,610,049–123,884,375, reverse strandMYLKDiagram of ADCY5: 21 exons on the reverse strand of chromosome 3Exon 18: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 21: 123,282,296–123,284,736, 2,441 basesExon 20: 123,286,685–123,286,809, 125 basesExon 19: 123,289,750–123,289,954, 205 basesExon 18: 123,291,113–123,291,376, 264 basesExon 17: 123,296,084–123,296,216, 133 basesExon 16: 123,297,353–123,297,382, 30 basesExon 15: 123,300,120–123,300,295, 176 basesExon 14: 123,303,055–123,303,219, 165 basesExon 13: 123,304,067–123,304,183, 117 basesExon 12: 123,314,235–123,314,322, 88 basesExon 11: 123,318,020–123,318,117, 98 basesExon 10: 123,319,674–123,319,818, 145 basesExon 9: 123,320,749–123,320,771, 23 basesExon 8: 123,325,322–123,325,462, 141 basesExon 7: 123,327,618–123,327,759, 142 basesExon 6: 123,328,644–123,328,802, 159 basesExon 5: 123,330,889–123,331,016, 128 basesExon 4: 123,332,564–123,332,675, 112 basesExon 3: 123,347,782–123,347,903, 122 basesExon 2: 123,352,432–123,352,581, 150 basesExon 1: 123,447,412–123,449,090, 1,679 bases2115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.6 kb of the gene's 166.8 kb; 3,786 of those bases code for the protein.

How a genome test reads ADCY5

17

positions in ADCY5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 166.8 kb of ADCY5, introns included, not only the 6.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADCY5 gene: adenylate cyclase 5. Retrieved 16 October 2026, from https://dantelabs.com/genes/adcy5

Vancouver

Dante Labs. ADCY5 gene: adenylate cyclase 5 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adcy5

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