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Gene

PPP2R5D

protein phosphatase 2 regulatory subunit B'delta

Summary

Cytogenetic location
6p21.1
Coordinates
Chromosome 6: 42,984,570–43,012,342 (GRCh38)
Exons
16 exons across 27.8 kb
Protein
602 amino acids
Also known as
B56D, B56delta
MANE Select transcript
ENST00000485511.6NM_006245.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How PPP2R5D is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where PPP2R5D sits. PPP2R5D and 28 genes near it on chromosome 6, from 42,498,456 to 43,498,455.Chromosome 66p21.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2742.6 Mb42.8 Mb43 Mb43.2 Mb43.4 MbUBR2: 42,563,969–42,693,505, forward strandUBR2PRPH2: 42,696,598–42,722,621, reverse strandPRPH2TBCC: 42,744,498–42,746,103, reverse strandTBCCBICRAL: 42,781,931–42,868,560, forward strandBICRALRPL7L1: 42,879,602–42,889,925, forward strandRPL7L1PEX39: 42,890,265–42,890,821, reverse strandPEX39PTCRA: 42,915,989–42,925,845, forward strandPTCRACNPY3: 42,928,975–42,940,217, forward strandCNPY3PEX6: 42,959,717–42,979,249, reverse strandPEX6GNMT: 42,960,268–42,970,699, forward strandGNMTPPP2R5D: 42,984,570–43,012,342, forward strandPPP2R5DMEA1: 43,011,143–43,016,868, reverse strandMEA1KLHDC3: 43,014,103–43,021,314, forward strandKLHDC3RRP36: 43,021,588–43,034,156, forward strandRRP36CUL7: 43,037,617–43,053,943, reverse strandKLC4: 43,040,777–43,075,099, forward strand: 43,051,066–43,058,185, reverse strandMRPL2: 43,054,029–43,059,464, reverse strandPTK7: 43,076,256–43,161,719, forward strandPTK7SRF: 43,170,910–43,181,506, forward strandSRFCUL9: 43,182,166–43,224,587, forward strandCUL9DNPH1: 43,225,629–43,229,490, reverse strandDNPH1TTBK1: 43,243,481–43,288,258, forward strandTTBK1SLC22A7: 43,295,694–43,305,543, forward strandSLC22A7CRIP3: 43,299,710–43,308,878, reverse strandCRIP3ZNF318: 43,307,134–43,369,687, reverse strandZNF318ABCC10: 43,427,366–43,451,783, forward strandABCC10DLK2: 43,450,351–43,456,632, reverse strandDLK2TJAP1: 43,477,523–43,506,562, forward strandTJAP1Diagram of PPP2R5D: 16 exons on the forward strand of chromosome 6Exon 4: 2 known disease-causing sitesExon 5: 9 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 4 known disease-causing sitesExon 1: 42,984,570–42,984,704, 135 basesExon 2: 42,989,611–42,989,688, 78 basesExon 3: 43,006,463–43,006,679, 217 basesExon 4: 43,006,911–43,007,110, 200 basesExon 5: 43,007,196–43,007,306, 111 basesExon 6: 43,007,414–43,007,506, 93 basesExon 7: 43,007,935–43,008,065, 131 basesExon 8: 43,008,201–43,008,260, 60 basesExon 9: 43,008,367–43,008,475, 109 basesExon 10: 43,008,693–43,008,746, 54 basesExon 11: 43,009,057–43,009,227, 171 basesExon 12: 43,009,322–43,009,449, 128 basesExon 13: 43,010,468–43,010,569, 102 basesExon 14: 43,010,664–43,010,736, 73 basesExon 15: 43,010,881–43,010,997, 117 basesExon 16: 43,011,149–43,012,342, 1,194 bases151015165′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3 kb of the gene's 27.8 kb; 1,809 of those bases code for the protein.

    How a genome test reads PPP2R5D

    16

    positions in PPP2R5D where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 27.8 kb of PPP2R5D, introns included, not only the 3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). PPP2R5D gene: protein phosphatase 2 regulatory subunit B'delta. Retrieved 16 October 2026, from https://dantelabs.com/genes/ppp2r5d

    Vancouver

    Dante Labs. PPP2R5D gene: protein phosphatase 2 regulatory subunit B'delta [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ppp2r5d

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