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Gene

AKT1

AKT serine/threonine kinase 1

Summary

Cytogenetic location
14q32.33
Coordinates
Chromosome 14: 104,769,349–104,795,748 (GRCh38)
Exons
15 exons across 26.4 kb
Protein
480 amino acids
Inheritance
Autosomal dominant
Also known as
RAC, PKB, PRKBA, AKT, RAC-alpha
MANE Select transcript
ENST00000649815.2NM_001382430.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Cowden Syndrome (PTEN hamartoma tumour syndrome)

    • PTEN hamartoma tumour syndromeAutosomal dominant

      The spectrum of PTEN-related conditions, including Cowden and Bannayan-Riley-Ruvalcaba syndromes, with hamartomas and raised risks of breast, thyroid, endometrial, kidney and other cancers.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Regular breast, thyroid, endometrial, kidney, bowel and skin surveillance, and testing of relatives.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How AKT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where AKT1 sits. AKT1 and 16 genes near it on chromosome 14, from 104,282,549 to 105,282,548.Chromosome 1414q32.33p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.33104.4 Mb104.6 Mb104.8 Mb105 Mb105.2 MbTMEM179: 104,474,678–104,605,647, reverse strandTMEM179C14orf180: 104,579,550–104,590,515, forward strandC14orf180INF2: 104,681,146–104,722,535, forward strandINF2ADSS1: 104,724,174–104,747,523, forward strandADSS1SIVA1: 104,753,122–104,768,494, forward strandSIVA1AKT1: 104,769,349–104,795,748, reverse strandAKT1ZBTB42: 104,799,415–104,804,712, forward strandZBTB42CEP170B: 104,864,498–104,896,770, forward strandCEP170BPLD4: 104,924,713–104,937,784, forward strandPLD4AHNAK2: 104,937,244–104,978,374, reverse strandAHNAK2CLBA1: 104,985,758–105,010,482, forward strandCLBA1CDCA4: 105,008,532–105,033,828, reverse strandCDCA4GPR132: 105,048,658–105,065,940, reverse strandGPR132JAG2: 105,140,982–105,168,919, reverse strandJAG2NUDT14: 105,172,937–105,181,323, reverse strandNUDT14BRF1: 105,209,277–105,315,589, reverse strandBRF1BTBD6: 105,248,533–105,251,125, forward strandBTBD6Diagram of AKT1: 15 exons on the reverse strand of chromosome 14Exon 12: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 15: 104,769,349–104,770,420, 1,072 basesExon 14: 104,770,745–104,770,847, 103 basesExon 13: 104,772,365–104,772,452, 88 basesExon 12: 104,772,878–104,773,092, 215 basesExon 11: 104,773,251–104,773,379, 129 basesExon 10: 104,773,455–104,773,580, 126 basesExon 9: 104,773,912–104,773,980, 69 basesExon 8: 104,774,938–104,775,003, 66 basesExon 7: 104,775,076–104,775,207, 132 basesExon 6: 104,775,652–104,775,799, 148 basesExon 5: 104,776,659–104,776,770, 112 basesExon 4: 104,780,088–104,780,216, 129 basesExon 3: 104,792,598–104,792,722, 125 basesExon 2: 104,793,127–104,793,304, 178 basesExon 1: 104,795,484–104,795,748, 265 bases1510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 26.4 kb; 1,443 of those bases code for the protein.

How a genome test reads AKT1

3

positions in AKT1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.4 kb of AKT1, introns included, not only the 3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AKT1 gene: AKT serine/threonine kinase 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/akt1

Vancouver

Dante Labs. AKT1 gene: AKT serine/threonine kinase 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/akt1

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