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Gene

SLC35A3

solute carrier family 35 member A3

Summary

Cytogenetic location
1p21.2
Coordinates
Chromosome 1: 99,969,996–100,035,634 (GRCh38)
Exons
8 exons across 65.6 kb
Protein
325 amino acids
MANE Select transcript
ENST00000533028.8NM_012243.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • 3 GenCC submitters rate it definitive or strong

    How SLC35A3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where SLC35A3 sits. SLC35A3 and 11 genes near it on chromosome 1, from 99,502,815 to 100,502,814.Chromosome 11p21.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4499.6 Mb99.8 Mb100 Mb100.2 Mb100.4 MbPALMD: 99,645,499–99,695,178, forward strandPALMDFRRS1: 99,703,970–99,766,642, reverse strandFRRS1AGL: 99,849,777–99,924,427, forward strandAGLSLC35A3: 99,969,996–100,035,634, forward strandSLC35A3: 99,970,011–100,083,321, forward strandSLC71A1: 100,038,076–100,083,948, forward strandSLC71A1SASS6: 100,083,563–100,132,955, reverse strandSASS6TRMT13: 100,133,043–100,151,150, forward strandTRMT13LRRC39: 100,146,522–100,178,306, reverse strandLRRC39DBT: 100,182,222–100,249,873, reverse strandDBTRTCA: 100,266,154–100,292,769, forward strandRTCACDC14A: 100,325,629–100,520,564, forward strandCDC14ADiagram of SLC35A3: 8 exons on the forward strand of chromosome 1Exon 2: 4 known disease-causing sitesExon 3: 10 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 10 known disease-causing sitesExon 6: 7 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 1: 99,969,996–99,970,162, 167 basesExon 2: 99,993,537–99,993,741, 205 basesExon 3: 99,999,261–99,999,415, 155 basesExon 4: 100,007,034–100,007,156, 123 basesExon 5: 100,011,365–100,011,533, 169 basesExon 6: 100,015,302–100,015,420, 119 basesExon 7: 100,017,682–100,017,815, 134 basesExon 8: 100,022,386–100,035,634, 13,249 bases123456785′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 14.3 kb of the gene's 65.6 kb; 978 of those bases code for the protein.

    How a genome test reads SLC35A3

    51

    positions in SLC35A3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 65.6 kb of SLC35A3, introns included, not only the 14.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SLC35A3 gene: solute carrier family 35 member A3. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc35a3

    Vancouver

    Dante Labs. SLC35A3 gene: solute carrier family 35 member A3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc35a3

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