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Gene

KLHL20

kelch like family member 20

Summary

Cytogenetic location
1q25.1
Coordinates
Chromosome 1: 173,714,981–173,786,692 (GRCh38)
Exons
12 exons across 71.7 kb
Protein
609 amino acids
Also known as
KLEIP, KHLHX
MANE Select transcript
ENST00000209884.5NM_014458.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KLHL20 yet. The test sequences your whole genome, so your data includes it all the same.

How KLHL20 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where KLHL20 sits. KLHL20 and 13 genes near it on chromosome 1, from 173,250,837 to 174,250,836.Chromosome 11q25.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44173.4 Mb173.6 Mb173.8 Mb174 Mb174.2 MbTNFSF4: 173,162,645–173,477,583, reverse strandTNFSF4PRDX6: 173,476,814–173,494,013, forward strandPRDX6SLC9C2: 173,500,460–173,603,077, reverse strandSLC9C2: 173,596,060–173,669,837, reverse strandANKRD45: 173,606,033–173,669,868, reverse strandANKRD45TEX50: 173,635,338–173,637,130, forward strandTEX50KLHL20: 173,714,981–173,786,692, forward strandKLHL20CENPL: 173,794,851–173,824,925, reverse strandCENPLDARS2: 173,824,540–173,858,808, forward strandDARS2ZBTB37: 173,868,082–173,903,547, forward strandZBTB37SERPINC1: 173,903,414–173,917,543, reverse strandSERPINC1RC3H1: 173,931,084–174,022,418, reverse strandRC3H1: 174,022,122–174,022,298, reverse strandRABGAP1L: 174,159,339–174,995,308, forward strandRABGAP1LDiagram of KLHL20: 12 exons on the forward strand of chromosome 1Exon 7: 1 known disease-causing siteExon 1: 173,714,981–173,715,078, 98 basesExon 2: 173,716,003–173,716,066, 64 basesExon 3: 173,733,713–173,734,286, 574 basesExon 4: 173,751,764–173,751,922, 159 basesExon 5: 173,753,213–173,753,307, 95 basesExon 6: 173,755,923–173,756,038, 116 basesExon 7: 173,756,976–173,757,159, 184 basesExon 8: 173,766,146–173,766,289, 144 basesExon 9: 173,774,305–173,774,438, 134 basesExon 10: 173,775,634–173,775,842, 209 basesExon 11: 173,782,124–173,782,230, 107 basesExon 12: 173,785,163–173,786,692, 1,530 bases1510125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 71.7 kb; 1,830 of those bases code for the protein.

How a genome test reads KLHL20

1

position in KLHL20 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 71.7 kb of KLHL20, introns included, not only the 3.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KLHL20 gene: kelch like family member 20. Retrieved 16 October 2026, from https://dantelabs.com/genes/klhl20

Vancouver

Dante Labs. KLHL20 gene: kelch like family member 20 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/klhl20

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