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Trait

Flat forehead

A forehead with abnormal flatness.

HPO HP:0004425

Summary

Also called
Flattened forehead, Frontal flattening
Body system
Abnormality of head or neck

18 genes linked to Flat forehead

Changes in these genes cause rare conditions in which Flat forehead is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DONSONDNA replication fork stabilization factor DONSONAlwaysIn 1 condition
ERI1exoribonuclease 1AlwaysIn 1 condition
ITPR1inositol 1,4,5-trisphosphate receptor type 1AlwaysIn 1 condition
IL11RAinterleukin 11 receptor subunit alphaOften (30–79%)In 1 condition
EXT2exostosin glycosyltransferase 2Sometimes (5–29%)In 1 condition
KCNH1potassium voltage-gated channel subfamily H member 1Sometimes (5–29%)In 1 condition
KNSTRNkinetochore localized astrin (SPAG5) binding proteinSometimes (5–29%)In 1 condition
PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaSometimes (5–29%)In 1 condition
PLAAT3phospholipase A and acyltransferase 3Sometimes (5–29%)In 1 condition
B4GALT7beta-1,4-galactosyltransferase 7Not recordedIn 1 condition
CAMK2Gcalcium/calmodulin dependent protein kinase II gammaNot recordedIn 1 condition
CHST14carbohydrate sulfotransferase 14Not recordedIn 1 condition
COG7component of oligomeric golgi complex 7Not recordedIn 1 condition
FGFR2fibroblast growth factor receptor 2Not recordedIn 1 condition
IARS2isoleucyl-tRNA synthetase 2, mitochondrialNot recordedIn 1 condition
LRP5LDL receptor related protein 5Not recordedIn 1 condition
RECQL4RecQ like helicase 4Not recordedIn 1 condition
TWIST1twist family bHLH transcription factor 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the forehead

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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