Trait

Upper airway obstruction

Increased resistance to the passage of air in the upper airway.

Body system: Abnormality of the respiratory system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/upper-airway-obstruction.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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16 genes linked to Upper airway obstruction

Changes in these genes cause rare conditions in which Upper airway obstruction is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AHDC1AT-hook DNA binding motif containing 1	Always	In 2 conditions
COL11A1collagen type XI alpha 1 chain	Very often (80–99%)	In 1 condition
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Very often (80–99%)	In 1 condition
KCNJ6potassium inwardly rectifying channel subfamily J member 6	Often (30–79%)	In 2 conditions
SOX9SRY-box transcription factor 9	Often (30–79%)	In 1 condition
BTNL2butyrophilin like 2	Sometimes (5–29%)	In 1 condition
DDRGK1DDRGK domain containing 1	Sometimes (5–29%)	In 1 condition
HLA-DRB1major histocompatibility complex, class II, DR beta 1	Sometimes (5–29%)	In 1 condition
LMNAlamin A/C	Sometimes (5–29%)	In 1 condition
SH3BP2SH3 domain binding protein 2	Sometimes (5–29%)	In 1 condition
XPNPEP2X-prolyl aminopeptidase 2	Sometimes (5–29%)	In 1 condition
ZMPSTE24zinc metallopeptidase STE24	Sometimes (5–29%)	In 1 condition
ZSWIM6zinc finger SWIM-type containing 6	Sometimes (5–29%)	In 2 conditions
FGFR2fibroblast growth factor receptor 2	Not recorded	In 1 condition
FGFR3fibroblast growth factor receptor 3	Not recorded	In 1 condition
PORcytochrome p450 oxidoreductase	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Episodic upper airway obstruction1 gene

Broader traits

Obstructive lung disease

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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