Trait
Pigeon chest
Clinical name: Pectus carinatum
A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Pigeon chest, and the rest of your genome, with one test.
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Get my Genome Test182 genes linked to Pigeon chest
Changes in these genes cause rare conditions in which Pigeon chest is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ASH1LASH1 like histone lysine methyltransferase | Always | In 1 condition |
| BRD4bromodomain containing 4 | Always | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Always | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Always | In 6 conditions |
| CUL7cullin 7 | Always | In 1 condition |
| ERI1exoribonuclease 1 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| FRYLFRY like transcription coactivator | Always | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Always | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Always | In 1 condition |
| GTPBP1GTP binding protein 1 | Always | In 1 condition |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KRT5keratin 5 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| MARS2methionyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| MBTPS1membrane bound transcription factor peptidase, site 1 | Always | In 1 condition |
| OBSL1obscurin like cytoskeletal adaptor 1 | Always | In 1 condition |
| PLAAphospholipase A2 activating protein | Always | In 2 conditions |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Always | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Always | In 1 condition |
| RAB33BRAB33B, member RAS oncogene family | Always | In 1 condition |
| SLC12A2solute carrier family 12 member 2 | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| SP7Sp7 transcription factor | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 4 conditions |
| CBLCbl proto-oncogene | Very often (80–99%) | In 1 condition |
| DYMdymeclin | Very often (80–99%) | In 2 conditions |
| FBN1fibrillin 1 | Very often (80–99%) | In 5 conditions |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 3 conditions |
| LZTR1leucine zipper like post translational regulator 1 | Very often (80–99%) | In 3 conditions |
| MRASmuscle RAS oncogene homolog | Very often (80–99%) | In 1 condition |
| NEU1neuraminidase 1 | Very often (80–99%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Very often (80–99%) | In 3 conditions |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 2 conditions |
Show 142 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RASA2RAS p21 protein activator 2 | Very often (80–99%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Very often (80–99%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Very often (80–99%) | In 3 conditions |
| RRASRAS related | Very often (80–99%) | In 1 condition |
| RRAS2RAS related 2 | Very often (80–99%) | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Very often (80–99%) | In 1 condition |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Very often (80–99%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Very often (80–99%) | In 2 conditions |
| ACTBactin beta | Often (30–79%) | In 1 condition |
| AGAaspartylglucosaminidase | Often (30–79%) | In 1 condition |
| ARSBarylsulfatase B | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 2 conditions |
| BMP1bone morphogenetic protein 1 | Often (30–79%) | In 1 condition |
| CBScystathionine beta-synthase | Often (30–79%) | In 2 conditions |
| DDR2discoidin domain receptor tyrosine kinase 2 | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| FLNBfilamin B | Often (30–79%) | In 3 conditions |
| FN1fibronectin 1 | Often (30–79%) | In 2 conditions |
| GZF1GDNF inducible zinc finger protein 1 | Often (30–79%) | In 1 condition |
| HBA1hemoglobin subunit alpha 1 | Often (30–79%) | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 2 conditions |
| MAXMYC associated transcriptional regulator X | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Often (30–79%) | In 2 conditions |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 2 conditions |
| NALCNsodium leak channel, non-selective | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 2 conditions |
| NKAPNFKB activating protein | Often (30–79%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 1 condition |
| NKX3-2NK3 homeobox 2 | Often (30–79%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Often (30–79%) | In 1 condition |
| PIGSphosphatidylinositol glycan anchor biosynthesis class S | Often (30–79%) | In 1 condition |
| PPP1R21protein phosphatase 1 regulatory subunit 21 | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 1 condition |
| SIL1SIL1 nucleotide exchange factor | Often (30–79%) | In 1 condition |
| SKISKI proto-oncogene | Often (30–79%) | In 2 conditions |
| SOX5SRY-box transcription factor 5 | Often (30–79%) | In 2 conditions |
| SV2Asynaptic vesicle glycoprotein 2A | Often (30–79%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Often (30–79%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 2 conditions |
| TNFRSF11ATNF receptor superfamily member 11a | Often (30–79%) | In 1 condition |
| TNFRSF11BTNF receptor superfamily member 11b | Often (30–79%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Often (30–79%) | In 3 conditions |
| TRAF7TNF receptor associated factor 7 | Often (30–79%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Often (30–79%) | In 2 conditions |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 2 conditions |
| VPS37AVPS37A subunit of ESCRT-I | Often (30–79%) | In 2 conditions |
| XYLT2xylosyltransferase 2 | Often (30–79%) | In 1 condition |
| ZNF668zinc finger protein 668 | Often (30–79%) | In 1 condition |
| AP1G1adaptor related protein complex 1 subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| ARL3ARF like GTPase 3 | Sometimes (5–29%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Sometimes (5–29%) | In 2 conditions |
| ATP2B1ATPase plasma membrane Ca2+ transporting 1 | Sometimes (5–29%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Sometimes (5–29%) | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Sometimes (5–29%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Sometimes (5–29%) | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Sometimes (5–29%) | In 1 condition |
| DSTdystonin | Sometimes (5–29%) | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Sometimes (5–29%) | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Sometimes (5–29%) | In 1 condition |
| FAM149B1family with sequence similarity 149 member B1 | Sometimes (5–29%) | In 1 condition |
| FBN2fibrillin 2 | Sometimes (5–29%) | In 1 condition |
| FZD2frizzled class receptor 2 | Sometimes (5–29%) | In 1 condition |
| GLB1galactosidase beta 1 | Sometimes (5–29%) | In 1 condition |
| GORABgolgin, RAB6 interacting | Sometimes (5–29%) | In 1 condition |
| GPC3glypican 3 | Sometimes (5–29%) | In 1 condition |
| GTPBP2GTP binding protein 2 | Sometimes (5–29%) | In 1 condition |
| HDAC4histone deacetylase 4 | Sometimes (5–29%) | In 1 condition |
| HNRNPH1heterogeneous nuclear ribonucleoprotein H1 | Sometimes (5–29%) | In 1 condition |
| HNRNPH2heterogeneous nuclear ribonucleoprotein H2 | Sometimes (5–29%) | In 1 condition |
| IHHIndian hedgehog signaling molecule | Sometimes (5–29%) | In 2 conditions |
| IPO8importin 8 | Sometimes (5–29%) | In 2 conditions |
| LGI3leucine rich repeat LGI family member 3 | Sometimes (5–29%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 2 conditions |
| MED25mediator complex subunit 25 | Sometimes (5–29%) | In 2 conditions |
| MFAP5microfibril associated protein 5 | Sometimes (5–29%) | In 1 condition |
| MYF5myogenic factor 5 | Sometimes (5–29%) | In 1 condition |
| NOTCH2notch receptor 2 | Sometimes (5–29%) | In 1 condition |
| NXNnucleoredoxin | Sometimes (5–29%) | In 1 condition |
| PTF1Apancreas associated transcription factor 1a | Sometimes (5–29%) | In 1 condition |
| PTPMT1protein tyrosine phosphatase mitochondrial 1 | Sometimes (5–29%) | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Sometimes (5–29%) | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Sometimes (5–29%) | In 1 condition |
| RAP1BRAP1B, member of RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Sometimes (5–29%) | In 1 condition |
| RNF135ring finger protein 135 | Sometimes (5–29%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| ROR2ROR family WNT receptor 2 | Sometimes (5–29%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 3 conditions |
| SNX14sorting nexin 14 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| TBX3T-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TBX6T-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| TELO2telomere maintenance 2 | Sometimes (5–29%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 2 conditions |
| TOE1target of EGR1, exonuclease | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Sometimes (5–29%) | In 3 conditions |
| UBTFupstream binding transcription factor | Sometimes (5–29%) | In 1 condition |
| UPF3BUPF3B regulator of nonsense mediated mRNA decay | Sometimes (5–29%) | In 1 condition |
| WNT5AWnt family member 5A | Sometimes (5–29%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 3 conditions |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Rarely (1–4%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| NEK1NIMA related kinase 1 | Rarely (1–4%) | In 1 condition |
| SMSspermine synthase | Rarely (1–4%) | In 2 conditions |
| TBCDtubulin folding cofactor D | Rarely (1–4%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Not recorded | In 1 condition |
| BGNbiglycan | Not recorded | In 1 condition |
| CHRM3cholinergic receptor muscarinic 3 | Not recorded | In 1 condition |
| COG4component of oligomeric golgi complex 4 | Not recorded | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Not recorded | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Not recorded | In 1 condition |
| FKBP10FKBP prolyl isomerase 10 | Not recorded | In 1 condition |
| G6PC3glucose-6-phosphatase catalytic subunit 3 | Not recorded | In 1 condition |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Not recorded | In 1 condition |
| GUSBglucuronidase beta | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KIF7kinesin family member 7 | Not recorded | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Not recorded | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PLOD2procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Not recorded | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Not recorded | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Not recorded | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Not recorded | In 1 condition |
| TRIP11thyroid hormone receptor interactor 11 | Not recorded | In 1 condition |
| WNT7AWnt family member 7A | Not recorded | In 1 condition |
| ZDHHC9zDHHC palmitoyltransferase 9 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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