Trait
Cupped ear
Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura).
Summary
- Also called
- Cup-shaped ears, Simple, cup-shaped ears
- Body system
- Abnormality of the ear
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test79 genes linked to Cupped ear
Changes in these genes cause rare conditions in which Cupped ear is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DDX11DEAD/H-box helicase 11 | Always | In 1 condition |
| ECE1endothelin converting enzyme 1 | Always | In 1 condition |
| EYA1EYA transcriptional coactivator and phosphatase 1 | Always | In 3 conditions |
| FGFR2fibroblast growth factor receptor 2 | Always | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Always | In 2 conditions |
| IGBP1immunoglobulin binding protein 1 | Always | In 2 conditions |
| ODC1ornithine decarboxylase 1 | Always | In 1 condition |
| PAX1paired box 1 | Always | In 1 condition |
| SPOUT1SPOUT domain containing methyltransferase 1 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| WLSWnt ligand secretion mediator | Always | In 1 condition |
| ZMYM3zinc finger MYM-type containing 3 | Always | In 1 condition |
| DHODHdihydroorotate dehydrogenase (quinone) | Very often (80–99%) | In 2 conditions |
| PQBP1polyglutamine binding protein 1 | Very often (80–99%) | In 4 conditions |
| DACT1dishevelled binding antagonist of beta catenin 1 | Often (30–79%) | In 1 condition |
| DHCR2424-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| EDNRAendothelin receptor type A | Often (30–79%) | In 1 condition |
| ERI1exoribonuclease 1 | Often (30–79%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Often (30–79%) | In 2 conditions |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 2 conditions |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 1 condition |
| LRRC8Cleucine rich repeat containing 8 VRAC subunit C | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| POU3F3POU class 3 homeobox 3 | Often (30–79%) | In 1 condition |
| PRR12proline rich 12 | Often (30–79%) | In 1 condition |
| QRICH1glutamine rich 1 | Often (30–79%) | In 1 condition |
| SEPHS1selenophosphate synthetase 1 | Often (30–79%) | In 1 condition |
| SIX1SIX homeobox 1 | Often (30–79%) | In 1 condition |
| TBX2T-box transcription factor 2 | Often (30–79%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| AFF4ALF transcription elongation factor 4 | Sometimes (5–29%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Sometimes (5–29%) | In 1 condition |
| ASXL2ASXL transcriptional regulator 2 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BRWD3bromodomain and WD repeat domain containing 3 | Sometimes (5–29%) | In 1 condition |
| CHD5chromodomain helicase DNA binding protein 5 | Sometimes (5–29%) | In 1 condition |
| CSNK2A1casein kinase 2 alpha 1 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 2 conditions |
Show 39 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Sometimes (5–29%) | In 1 condition |
| EIF5Aeukaryotic translation initiation factor 5A | Sometimes (5–29%) | In 1 condition |
| FBXW11F-box and WD repeat domain containing 11 | Sometimes (5–29%) | In 1 condition |
| FEM1Bfem-1 homolog B | Sometimes (5–29%) | In 1 condition |
| HYAL2hyaluronidase 2 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| MED16mediator complex subunit 16 | Sometimes (5–29%) | In 1 condition |
| PGAP2post-GPI attachment to proteins 2 | Sometimes (5–29%) | In 1 condition |
| PGAP3post-GPI attachment to proteins phospholipase 3 | Sometimes (5–29%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Sometimes (5–29%) | In 1 condition |
| PIGOphosphatidylinositol glycan anchor biosynthesis class O | Sometimes (5–29%) | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Sometimes (5–29%) | In 1 condition |
| PIGWphosphatidylinositol glycan anchor biosynthesis class W | Sometimes (5–29%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Sometimes (5–29%) | In 1 condition |
| PLXNA1plexin A1 | Sometimes (5–29%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Sometimes (5–29%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| SCNM1sodium channel modifier 1 | Sometimes (5–29%) | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Sometimes (5–29%) | In 1 condition |
| SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZNF292zinc finger protein 292 | Sometimes (5–29%) | In 1 condition |
| SMSspermine synthase | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ZNF462zinc finger protein 462 | Rarely (1–4%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Not recorded | In 1 condition |
| CHD4chromodomain helicase DNA binding protein 4 | Not recorded | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Not recorded | In 1 condition |
| FOXL2forkhead box L2 | Not recorded | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Not recorded | In 1 condition |
| GNAI3G protein subunit alpha i3 | Not recorded | In 1 condition |
| HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 | Not recorded | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Not recorded | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Not recorded | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Not recorded | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Not recorded | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Not recorded | In 1 condition |
| TCF4transcription factor 4 | Not recorded | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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