Trait

Corneal perforation

A rupture of the cornea through which a portion of the iris protrudes.

Also called: Iridocele
Body system: Abnormality of the eye

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/corneal-perforation.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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14 genes linked to Corneal perforation

Changes in these genes cause rare conditions in which Corneal perforation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PRDM5PR/SET domain 5	Often (30–79%)	In 2 conditions
ZNF469zinc finger protein 469	Often (30–79%)	In 1 condition
FOXE3forkhead box E3	Sometimes (5–29%)	In 1 condition
ABCA12ATP binding cassette subfamily A member 12	Rarely (1–4%)	In 1 condition
ALOX12Barachidonate 12-lipoxygenase, 12R type	Rarely (1–4%)	In 1 condition
ALOXE3arachidonate epidermal lipoxygenase 3	Rarely (1–4%)	In 1 condition
ASPRV1aspartic peptidase retroviral like 1	Rarely (1–4%)	In 1 condition
CYP4F22cytochrome P450 family 4 subfamily F member 22	Rarely (1–4%)	In 1 condition
LIPNlipase family member N	Rarely (1–4%)	In 1 condition
NIPAL4NIPA like domain containing 4	Rarely (1–4%)	In 1 condition
SDR9C7short chain dehydrogenase/reductase family 9C member 7	Rarely (1–4%)	In 1 condition
SULT2B1sulfotransferase family 2B member 1	Rarely (1–4%)	In 1 condition
TGM1transglutaminase 1	Rarely (1–4%)	In 1 condition
FGFR2fibroblast growth factor receptor 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal cornea morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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