Trait
Cutaneous syndactyly
A soft tissue continuity in the A/P axis between two digits that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two digits that lies significantly distal to the flexion crease that overlies the metacarpophalangeal or metatarsophalangeal joint of the adjacent digits.
Summary
- Also called
- Cutaneous syndactyly of digits, Syndactyly, cutaneous
Reference genomeGRCh38hg38
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Read the genes linked to Cutaneous syndactyly, and the rest of your genome, with one test.
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Get my Genome Test25 genes linked to Cutaneous syndactyly
Changes in these genes cause rare conditions in which Cutaneous syndactyly is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 2 conditions |
| CEP55centrosomal protein 55 | Always | In 1 condition |
| DDX59DEAD-box helicase 59 | Always | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Always | In 2 conditions |
| FRAS1Fraser extracellular matrix complex subunit 1 | Very often (80–99%) | In 1 condition |
| FREM2FRAS1 related extracellular matrix 2 | Very often (80–99%) | In 2 conditions |
| ANKRD11ankyrin repeat domain 11 | Often (30–79%) | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Sometimes (5–29%) | In 1 condition |
| CDH1cadherin 1 | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 1 condition |
| KIF7kinesin family member 7 | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 2 conditions |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Rarely (1–4%) | In 1 condition |
| CTNND1catenin delta 1 | Rarely (1–4%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Rarely (1–4%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| BHLHA9basic helix-loop-helix family member a9 | Not recorded | In 1 condition |
| BLTP1bridge-like lipid transfer protein family member 1 | Not recorded | In 1 condition |
| CKAP2Lcytoskeleton associated protein 2L | Not recorded | In 1 condition |
| MEIS2Meis homeobox 2 | Not recorded | In 1 condition |
| RBM10RNA binding motif protein 10 | Not recorded | In 1 condition |
| TMEM94transmembrane protein 94 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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