Trait
Lost smell
Clinical name: Anosmia
An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.
Summary
- Also called
- Loss of smell
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test49 genes linked to Lost smell
Changes in these genes cause rare conditions in which Lost smell is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FEZF1FEZ family zinc finger 1 | Always | In 2 conditions |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Always | In 2 conditions |
| IL17RDinterleukin 17 receptor D | Always | In 2 conditions |
| NDNFneuron derived neurotrophic factor | Always | In 2 conditions |
| TCF12transcription factor 12 | Always | In 1 condition |
| ANOS1anosmin 1 | Very often (80–99%) | In 2 conditions |
| CCDC141coiled-coil domain containing 141 | Very often (80–99%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 4 conditions |
| DCCDCC netrin 1 receptor | Very often (80–99%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Very often (80–99%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Very often (80–99%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Very often (80–99%) | In 2 conditions |
| FGF8fibroblast growth factor 8 | Very often (80–99%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 3 conditions |
| FLRT3fibronectin leucine rich transmembrane protein 3 | Very often (80–99%) | In 1 condition |
| HESX1HESX homeobox 1 | Very often (80–99%) | In 2 conditions |
| PEX7peroxisomal biogenesis factor 7 | Very often (80–99%) | In 3 conditions |
| PHYHphytanoyl-CoA 2-hydroxylase | Very often (80–99%) | In 2 conditions |
| PROK2prokineticin 2 | Very often (80–99%) | In 2 conditions |
| PROKR2prokineticin receptor 2 | Very often (80–99%) | In 3 conditions |
| SEMA3Asemaphorin 3A | Very often (80–99%) | In 2 conditions |
| SEMA3Esemaphorin 3E | Very often (80–99%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Very often (80–99%) | In 2 conditions |
| SOX10SRY-box transcription factor 10 | Very often (80–99%) | In 4 conditions |
| SPRY4sprouty RTK signaling antagonist 4 | Very often (80–99%) | In 1 condition |
| TACR3tachykinin receptor 3 | Very often (80–99%) | In 1 condition |
| WDR11WD repeat domain 11 | Very often (80–99%) | In 2 conditions |
| ADCY3adenylate cyclase 3 | Often (30–79%) | In 1 condition |
| GNRH1gonadotropin releasing hormone 1 | Often (30–79%) | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Often (30–79%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Often (30–79%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Often (30–79%) | In 1 condition |
| ANK1ankyrin 1 | Sometimes (5–29%) | In 1 condition |
| ARNT2aryl hydrocarbon receptor nuclear translocator 2 | Sometimes (5–29%) | In 1 condition |
| KISS1RKISS1 receptor | Sometimes (5–29%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SHHsonic hedgehog signaling molecule | Sometimes (5–29%) | In 1 condition |
| SOX2SRY-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TAC3tachykinin precursor 3 | Sometimes (5–29%) | In 1 condition |
Show 9 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FGF10fibroblast growth factor 10 | Rarely (1–4%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Rarely (1–4%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Rarely (1–4%) | In 1 condition |
| ARSLarylsulfatase L | Not recorded | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Not recorded | In 1 condition |
| DNAI1dynein axonemal intermediate chain 1 | Not recorded | In 1 condition |
| FSHBfollicle stimulating hormone subunit beta | Not recorded | In 1 condition |
| MFN2mitofusin 2 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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