Trait

Small fingernail

Clinical name: Hypoplastic fingernail

Underdevelopment of a fingernail.

HPO HP:0001804

Also called: Underdeveloped fingernail
Body system: Abnormality of the integument

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/hypoplastic-fingernail.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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40 genes linked to Small fingernail

Changes in these genes cause rare conditions in which Small fingernail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ERI1exoribonuclease 1	Always	In 1 condition
FBXO28F-box protein 28	Always	In 1 condition
FGFR2fibroblast growth factor receptor 2	Always	In 1 condition
PIGOphosphatidylinositol glycan anchor biosynthesis class O	Always	In 1 condition
TBC1D24TBC1 domain family member 24	Always	In 1 condition
HYMAIhydatidiform mole associated and imprinted	Very often (80–99%)	In 1 condition
MSX1msh homeobox 1	Very often (80–99%)	In 1 condition
PIGNphosphatidylinositol glycan anchor biosynthesis class N	Very often (80–99%)	In 2 conditions
PLAGL1PLAG1 like zinc finger 1	Very often (80–99%)	In 1 condition
PLECplectin	Very often (80–99%)	In 1 condition
SHOXSHOX homeobox	Very often (80–99%)	In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2	Often (30–79%)	In 1 condition
CENPTcentromere protein T	Often (30–79%)	In 1 condition
COL11A1collagen type XI alpha 1 chain	Often (30–79%)	In 2 conditions
COL11A2collagen type XI alpha 2 chain	Often (30–79%)	In 1 condition
KCNH1potassium voltage-gated channel subfamily H member 1	Often (30–79%)	In 2 conditions
KCNN3potassium calcium-activated channel subfamily N member 3	Often (30–79%)	In 1 condition
MBTPS2membrane bound transcription factor peptidase, site 2	Often (30–79%)	In 1 condition
PIGFphosphatidylinositol glycan anchor biosynthesis class F	Often (30–79%)	In 1 condition
RPS6KA3ribosomal protein S6 kinase A3	Often (30–79%)	In 1 condition
ARHGAP31Rho GTPase activating protein 31	Sometimes (5–29%)	In 1 condition
CCDC22CCC complex scaffolding subunit CCDC22	Sometimes (5–29%)	In 1 condition
CDKN1Ccyclin dependent kinase inhibitor 1C	Sometimes (5–29%)	In 1 condition
DLL4delta like canonical Notch ligand 4	Sometimes (5–29%)	In 1 condition
DOCK6dedicator of cytokinesis 6	Sometimes (5–29%)	In 1 condition
DPYSL5dihydropyrimidinase like 5	Sometimes (5–29%)	In 1 condition
EOGTEGF domain specific O-linked N-acetylglucosamine transferase	Sometimes (5–29%)	In 1 condition
HMGA2high mobility group AT-hook 2	Sometimes (5–29%)	In 1 condition
IGF2insulin like growth factor 2	Sometimes (5–29%)	In 1 condition
NOTCH1notch receptor 1	Sometimes (5–29%)	In 1 condition
PLAG1PLAG1 zinc finger	Sometimes (5–29%)	In 1 condition
PTDSS1phosphatidylserine synthase 1	Sometimes (5–29%)	In 1 condition
RBPJrecombination signal binding protein for immunoglobulin kappa J region	Sometimes (5–29%)	In 1 condition
TWIST2twist family bHLH transcription factor 2	Sometimes (5–29%)	In 1 condition
VPS35LVPS35 endosomal protein sorting factor like	Sometimes (5–29%)	In 1 condition
WASHC5WASH complex subunit 5	Sometimes (5–29%)	In 1 condition
ZNF462zinc finger protein 462	Rarely (1–4%)	In 1 condition
BMPERBMP binding endothelial regulator	Not recorded	In 1 condition
ROR2ROR family WNT receptor 2	Not recorded	In 1 condition
TFAP2Atranscription factor AP-2 alpha	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal fingernails Small nail

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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