Trait

Early closure of midline skull joint

Clinical name: Sagittal craniosynostosis

A kind of craniosynostosis affecting the sagittal suture.

HPO HP:0004442

Also called: Midline skull joint closes early, Craniosynostosis, sagittal, Craniosynostosis, sagittal suture, Sagittal suture synostosis
Body system: Abnormality of head or neck Abnormality of the musculoskeletal system

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28 genes linked to Early closure of midline skull joint

Changes in these genes cause rare conditions in which Early closure of midline skull joint is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
EIF4A2eukaryotic translation initiation factor 4A2	Always	In 1 condition
IFT140intraflagellar transport 140	Always	In 1 condition
IL11RAinterleukin 11 receptor subunit alpha	Always	In 1 condition
PTH1Rparathyroid hormone 1 receptor	Always	In 1 condition
ERFETS2 repressor factor	Very often (80–99%)	In 1 condition
FGFR2fibroblast growth factor receptor 2	Often (30–79%)	In 2 conditions
HNRNPKheterogeneous nuclear ribonucleoprotein K	Often (30–79%)	In 3 conditions
IFT43intraflagellar transport 43	Often (30–79%)	In 1 condition
RNU12RNA, U12 small nuclear	Often (30–79%)	In 1 condition
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like	Often (30–79%)	In 1 condition
TWIST1twist family bHLH transcription factor 1	Often (30–79%)	In 1 condition
WDR19WD repeat domain 19	Often (30–79%)	In 1 condition
AHDC1AT-hook DNA binding motif containing 1	Sometimes (5–29%)	In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2	Sometimes (5–29%)	In 1 condition
CDC45cell division cycle 45	Sometimes (5–29%)	In 1 condition
DNMT3ADNA methyltransferase 3 alpha	Sometimes (5–29%)	In 1 condition
DPF2double PHD fingers 2	Sometimes (5–29%)	In 1 condition
DPH1diphthamide biosynthesis 1	Sometimes (5–29%)	In 2 conditions
DPH2diphthamide biosynthesis 2	Sometimes (5–29%)	In 1 condition
FBXO11F-box protein 11	Sometimes (5–29%)	In 1 condition
GLIS3GLIS family zinc finger 3	Sometimes (5–29%)	In 1 condition
KRASKRas proto-oncogene, GTPase	Sometimes (5–29%)	In 1 condition
SONSON DNA and RNA binding protein	Sometimes (5–29%)	In 1 condition
TBC1D24TBC1 domain family member 24	Sometimes (5–29%)	In 1 condition
TCF12transcription factor 12	Sometimes (5–29%)	In 1 condition
IFT122intraflagellar transport 122	Not recorded	In 1 condition
RAB23RAB23, member RAS oncogene family	Not recorded	In 1 condition
RECQL4RecQ like helicase 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Deformity of the skull

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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