Trait
Gum enlargement
Clinical name: Gingival overgrowth
Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown.
Summary
- Also called
- Gingival enlargement, Gingival hyperplasia, Gum hypertrophy, Hypertrophic gingivitis
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test124 genes linked to Gum enlargement
Changes in these genes cause rare conditions in which Gum enlargement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANKHANKH inorganic pyrophosphate transport regulator | Always | In 1 condition |
| ARID2AT-rich interaction domain 2 | Always | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Always | In 2 conditions |
| DVL3dishevelled segment polarity protein 3 | Always | In 2 conditions |
| FBXO28F-box protein 28 | Always | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Always | In 3 conditions |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| GLB1galactosidase beta 1 | Always | In 3 conditions |
| GPC3glypican 3 | Always | In 1 condition |
| KCNK4potassium two pore domain channel subfamily K member 4 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| MAP1Bmicrotubule associated protein 1B | Always | In 1 condition |
| NXNnucleoredoxin | Always | In 2 conditions |
| RIN2Ras and Rab interactor 2 | Always | In 2 conditions |
| SATB2SATB homeobox 2 | Always | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Always | In 2 conditions |
| TMCO1transmembrane and coiled-coil domains 1 | Always | In 1 condition |
| AGAaspartylglucosaminidase | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 3 conditions |
| CD96CD96 molecule | Very often (80–99%) | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Very often (80–99%) | In 3 conditions |
| FAM20AFAM20A golgi associated secretory pathway pseudokinase | Very often (80–99%) | In 2 conditions |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Very often (80–99%) | In 3 conditions |
| HYMAIhydatidiform mole associated and imprinted | Very often (80–99%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Very often (80–99%) | In 2 conditions |
| MMP2matrix metallopeptidase 2 | Very often (80–99%) | In 1 condition |
| PLAGL1PLAG1 like zinc finger 1 | Very often (80–99%) | In 1 condition |
| RESTRE1 silencing transcription factor | Very often (80–99%) | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Very often (80–99%) | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Very often (80–99%) | In 1 condition |
| ABCA5ATP binding cassette subfamily A member 5 | Often (30–79%) | In 1 condition |
| ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2 | Often (30–79%) | In 2 conditions |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Often (30–79%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Often (30–79%) | In 1 condition |
| AIMP2aminoacyl tRNA synthetase complex interacting multifunctional protein 2 | Often (30–79%) | In 1 condition |
| BGNbiglycan | Often (30–79%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Often (30–79%) | In 2 conditions |
| DHCR77-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| DNM1dynamin 1 | Often (30–79%) | In 1 condition |
| EMC1ER membrane protein complex subunit 1 | Often (30–79%) | In 2 conditions |
Show 84 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FAM20CFAM20C golgi associated secretory pathway kinase | Often (30–79%) | In 2 conditions |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 1 condition |
| FGF3fibroblast growth factor 3 | Often (30–79%) | In 1 condition |
| FZD2frizzled class receptor 2 | Often (30–79%) | In 1 condition |
| GUSBglucuronidase beta | Often (30–79%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Often (30–79%) | In 1 condition |
| KCNJ6potassium inwardly rectifying channel subfamily J member 6 | Often (30–79%) | In 2 conditions |
| KCNMA1potassium calcium-activated channel subfamily M alpha 1 | Often (30–79%) | In 1 condition |
| KCNN3potassium calcium-activated channel subfamily N member 3 | Often (30–79%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Often (30–79%) | In 1 condition |
| NFIXnuclear factor I X | Often (30–79%) | In 3 conditions |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Often (30–79%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 2 conditions |
| PIGSphosphatidylinositol glycan anchor biosynthesis class S | Often (30–79%) | In 1 condition |
| PLGplasminogen | Often (30–79%) | In 2 conditions |
| PRMT7protein arginine methyltransferase 7 | Often (30–79%) | In 1 condition |
| RALGAPA1Ral GTPase activating protein catalytic subunit alpha 1 | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| ROR2ROR family WNT receptor 2 | Often (30–79%) | In 2 conditions |
| SC5Dsterol-C5-desaturase | Often (30–79%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Often (30–79%) | In 2 conditions |
| TBC1D2BTBC1 domain family member 2B | Often (30–79%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Often (30–79%) | In 1 condition |
| WNT5AWnt family member 5A | Often (30–79%) | In 2 conditions |
| ZNHIT3zinc finger HIT-type containing 3 | Often (30–79%) | In 1 condition |
| AFF3ALF transcription elongation factor 3 | Sometimes (5–29%) | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Sometimes (5–29%) | In 1 condition |
| ATG7autophagy related 7 | Sometimes (5–29%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 2 conditions |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Sometimes (5–29%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| MYSM1Myb like, SWIRM and MPN domains 1 | Sometimes (5–29%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 1 condition |
| NEU1neuraminidase 1 | Sometimes (5–29%) | In 2 conditions |
| NKX6-2NK6 homeobox 2 | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Sometimes (5–29%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 1 condition |
| PMLPML nuclear body scaffold | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| RARAretinoic acid receptor alpha | Sometimes (5–29%) | In 1 condition |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Sometimes (5–29%) | In 1 condition |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Sometimes (5–29%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| WDR26WD repeat domain 26 | Sometimes (5–29%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 2 conditions |
| KIF7kinesin family member 7 | Rarely (1–4%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Not recorded | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Not recorded | In 1 condition |
| MMP14matrix metallopeptidase 14 | Not recorded | In 1 condition |
| SLC17A5solute carrier family 17 member 5 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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