Trait
Visual loss
Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that).
Summary
- Also called
- Loss of vision, Vision loss
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test166 genes linked to Visual loss
Changes in these genes cause rare conditions in which Visual loss is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Always | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| MECRmitochondrial trans-2-enoyl-CoA reductase | Always | In 1 condition |
| MYO7Amyosin VIIA | Always | In 3 conditions |
| PEX13peroxisomal biogenesis factor 13 | Always | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 1 condition |
| SOSTsclerostin | Always | In 1 condition |
| SPATA7spermatogenesis associated 7 | Always | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Always | In 2 conditions |
| TEFMtranscription elongation factor, mitochondrial | Always | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Always | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Always | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Always | In 1 condition |
| USH1CUSH1 protein network component harmonin | Always | In 2 conditions |
| ADGRV1adhesion G protein-coupled receptor V1 | Very often (80–99%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Very often (80–99%) | In 2 conditions |
| ARSGarylsulfatase G | Very often (80–99%) | In 1 condition |
| CDH23cadherin related 23 | Very often (80–99%) | In 1 condition |
| CEP78centrosomal protein 78 | Very often (80–99%) | In 1 condition |
| CFHcomplement factor H | Very often (80–99%) | In 1 condition |
| CFIcomplement factor I | Very often (80–99%) | In 1 condition |
| CLRN1clarin 1 | Very often (80–99%) | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Very often (80–99%) | In 1 condition |
| ELMO2engulfment and cell motility 2 | Very often (80–99%) | In 1 condition |
| ESPNespin | Very often (80–99%) | In 1 condition |
| FOXC1forkhead box C1 | Very often (80–99%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Very often (80–99%) | In 1 condition |
| HLA-Amajor histocompatibility complex, class I, A | Very often (80–99%) | In 1 condition |
| ISCA2iron-sulfur cluster assembly 2 | Very often (80–99%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Very often (80–99%) | In 2 conditions |
| NHSNHS actin remodeling regulator | Very often (80–99%) | In 2 conditions |
| PAX6paired box 6 | Very often (80–99%) | In 1 condition |
| PCDH15protocadherin related 15 | Very often (80–99%) | In 1 condition |
| PDZD7PDZ domain containing 7 | Very often (80–99%) | In 1 condition |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| TGFBItransforming growth factor beta induced | Very often (80–99%) | In 1 condition |
| TIMP3TIMP metallopeptidase inhibitor 3 | Very often (80–99%) | In 1 condition |
| TRIM44TRIM family member 44 | Very often (80–99%) | In 1 condition |
| USH1GUSH1 protein network component sans | Very often (80–99%) | In 1 condition |
Show 126 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| USH2Ausherin | Very often (80–99%) | In 1 condition |
| WHRNwhirlin | Very often (80–99%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Very often (80–99%) | In 1 condition |
| ZNHIT3zinc finger HIT-type containing 3 | Very often (80–99%) | In 1 condition |
| AGBL1AGBL carboxypeptidase 1 | Often (30–79%) | In 1 condition |
| ATXN7ataxin 7 | Often (30–79%) | In 1 condition |
| C1QTNF5C1q and TNF related 5 | Often (30–79%) | In 2 conditions |
| COL18A1collagen type XVIII alpha 1 chain | Often (30–79%) | In 1 condition |
| COL8A2collagen type VIII alpha 2 chain | Often (30–79%) | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Often (30–79%) | In 1 condition |
| GALCgalactosylceramidase | Often (30–79%) | In 3 conditions |
| GATA2GATA binding protein 2 | Often (30–79%) | In 1 condition |
| GJB2gap junction protein beta 2 | Often (30–79%) | In 1 condition |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 1 condition |
| GUCA1Aguanylate cyclase activator 1A | Often (30–79%) | In 1 condition |
| GUCY2Dguanylate cyclase 2D, retinal | Often (30–79%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Often (30–79%) | In 1 condition |
| HSD17B4hydroxysteroid 17-beta dehydrogenase 4 | Often (30–79%) | In 1 condition |
| LAMC3laminin subunit gamma 3 | Often (30–79%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Often (30–79%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Often (30–79%) | In 2 conditions |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Often (30–79%) | In 2 conditions |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Often (30–79%) | In 2 conditions |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Often (30–79%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Often (30–79%) | In 2 conditions |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Often (30–79%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Often (30–79%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Often (30–79%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Often (30–79%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Often (30–79%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Often (30–79%) | In 1 condition |
| PAK2p21 (RAC1) activated kinase 2 | Often (30–79%) | In 1 condition |
| PMPCBpeptidase, mitochondrial processing subunit beta | Often (30–79%) | In 1 condition |
| PRDM5PR/SET domain 5 | Often (30–79%) | In 1 condition |
| PRPH2peripherin 2 | Often (30–79%) | In 1 condition |
| SLC4A11solute carrier family 4 member 11 | Often (30–79%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Often (30–79%) | In 2 conditions |
| SOX2SRY-box transcription factor 2 | Often (30–79%) | In 1 condition |
| TCF4transcription factor 4 | Often (30–79%) | In 1 condition |
| ZEB1zinc finger E-box binding homeobox 1 | Often (30–79%) | In 1 condition |
| ZNF469zinc finger protein 469 | Often (30–79%) | In 2 conditions |
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Sometimes (5–29%) | In 1 condition |
| ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 | Sometimes (5–29%) | In 1 condition |
| AHI1Abelson helper integration site 1 | Sometimes (5–29%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CD247CD247 molecule | Sometimes (5–29%) | In 1 condition |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 1 condition |
| CEP41centrosomal protein 41 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CSPP1centrosome and spindle pole associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CYP1B1cytochrome P450 family 1 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Sometimes (5–29%) | In 1 condition |
| DUX4double homeobox 4 | Sometimes (5–29%) | In 1 condition |
| DUX4L1double homeobox 4 like 1 (pseudogene) | Sometimes (5–29%) | In 1 condition |
| EPRS1glutamyl-prolyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 1 condition |
| FRG1FSHD region gene 1 | Sometimes (5–29%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| HCCSholocytochrome c synthase | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Sometimes (5–29%) | In 2 conditions |
| IL2RAinterleukin 2 receptor subunit alpha | Sometimes (5–29%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Sometimes (5–29%) | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Sometimes (5–29%) | In 1 condition |
| KCTD7potassium channel tetramerization domain containing 7 | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Sometimes (5–29%) | In 2 conditions |
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| MMP1matrix metallopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| MYOCmyocilin | Sometimes (5–29%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Sometimes (5–29%) | In 1 condition |
| NEU1neuraminidase 1 | Sometimes (5–29%) | In 2 conditions |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Sometimes (5–29%) | In 2 conditions |
| NOD2nucleotide binding oligomerization domain containing 2 | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PGK1phosphoglycerate kinase 1 | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 2 conditions |
| SLC19A2solute carrier family 19 member 2 | Sometimes (5–29%) | In 2 conditions |
| SLC52A2solute carrier family 52 member 2 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TATtyrosine aminotransferase | Sometimes (5–29%) | In 1 condition |
| TEKTEK receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Sometimes (5–29%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Sometimes (5–29%) | In 1 condition |
| VCANversican | Sometimes (5–29%) | In 2 conditions |
| VHLvon Hippel-Lindau tumor suppressor | Sometimes (5–29%) | In 1 condition |
| WACWW domain containing adaptor with coiled-coil | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ABCA4ATP binding cassette subfamily A member 4 | Not recorded | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| ALPK1alpha kinase 1 | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Not recorded | In 1 condition |
| BCORBCL6 corepressor | Not recorded | In 1 condition |
| BTDbiotinidase | Not recorded | In 1 condition |
| CA2carbonic anhydrase 2 | Not recorded | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| CTSDcathepsin D | Not recorded | In 1 condition |
| EPM2AEPM2A glucan phosphatase, laforin | Not recorded | In 1 condition |
| IFT140intraflagellar transport 140 | Not recorded | In 1 condition |
| LCA5lebercilin LCA5 | Not recorded | In 1 condition |
| LSSlanosterol synthase | Not recorded | In 1 condition |
| MFSD8major facilitator superfamily domain containing 8 | Not recorded | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Not recorded | In 1 condition |
| MT-ND4Lmitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L | Not recorded | In 1 condition |
| PLA2G6phospholipase A2 group VI | Not recorded | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Not recorded | In 1 condition |
| ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | Not recorded | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Not recorded | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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