Trait

Decreased depth of eye sockets

Clinical name: Shallow orbits

Reduced depth of the orbits associated with prominent-appearing ocular globes.

HPO HP:0000586

Also called: Shallow eye sockets, Decreased depth of orbits, Small shallow orbits
Body system: Abnormality of head or neck Abnormality of the eye Abnormality of the musculoskeletal system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/shallow-orbits.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Decreased depth of eye sockets, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

36 genes linked to Decreased depth of eye sockets

Changes in these genes cause rare conditions in which Decreased depth of eye sockets is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ANTXR1ANTXR cell adhesion molecule 1	Always	In 1 condition
CACNA1Ccalcium voltage-gated channel subunit alpha1 C	Always	In 1 condition
LEMD2LEM domain nuclear envelope protein 2	Always	In 1 condition
PLOD3procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Always	In 1 condition
SERPINH1serpin family H member 1	Always	In 1 condition
HYMAIhydatidiform mole associated and imprinted	Very often (80–99%)	In 1 condition
INPPL1inositol polyphosphate phosphatase like 1	Very often (80–99%)	In 1 condition
PLAGL1PLAG1 like zinc finger 1	Very often (80–99%)	In 1 condition
COL11A1collagen type XI alpha 1 chain	Often (30–79%)	In 1 condition
FGFR2fibroblast growth factor receptor 2	Often (30–79%)	In 5 conditions
HNRNPKheterogeneous nuclear ribonucleoprotein K	Often (30–79%)	In 3 conditions
KCNJ6potassium inwardly rectifying channel subfamily J member 6	Often (30–79%)	In 2 conditions
LMNAlamin A/C	Often (30–79%)	In 1 condition
MAFMAF bZIP transcription factor	Often (30–79%)	In 1 condition
MITFmelanocyte inducing transcription factor	Often (30–79%)	In 1 condition
SETBP1SET binding protein 1	Often (30–79%)	In 2 conditions
SHPKsedoheptulokinase	Often (30–79%)	In 1 condition
SKISKI proto-oncogene	Often (30–79%)	In 1 condition
ZMPSTE24zinc metallopeptidase STE24	Often (30–79%)	In 1 condition
ALG9ALG9 alpha-1,2-mannosyltransferase	Sometimes (5–29%)	In 1 condition
DBR1debranching RNA lariats 1	Sometimes (5–29%)	In 1 condition
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Sometimes (5–29%)	In 1 condition
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	Sometimes (5–29%)	In 1 condition
MTX2metaxin 2	Sometimes (5–29%)	In 1 condition
PDGFRBplatelet derived growth factor receptor beta	Sometimes (5–29%)	In 1 condition
POLA1DNA polymerase alpha 1, catalytic subunit	Sometimes (5–29%)	In 1 condition
PTCH1patched 1	Sometimes (5–29%)	In 1 condition
SIN3ASIN3 transcription regulator family member A	Sometimes (5–29%)	In 1 condition
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10	Not recorded	In 1 condition
ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2	Not recorded	In 1 condition
FBN1fibrillin 1	Not recorded	In 1 condition
FGFR1fibroblast growth factor receptor 1	Not recorded	In 2 conditions
FLNBfilamin B	Not recorded	In 1 condition
NFIXnuclear factor I X	Not recorded	In 1 condition
P4HBprolyl 4-hydroxylase subunit beta	Not recorded	In 1 condition
TWIST1twist family bHLH transcription factor 1	Not recorded	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal morphology of bony orbit of skull Bulging eye

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.