Trait
Fullness around the eyes
Clinical name: Periorbital fullness
Increase in periorbital soft tissue.
Summary
- Also called
- Puffiness around eye, Periorbital puffiness, Periorbital swelling, Puffy eyes, Swelling around the eyes
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test50 genes linked to Fullness around the eyes
Changes in these genes cause rare conditions in which Fullness around the eyes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARID2AT-rich interaction domain 2 | Always | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Always | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Always | In 1 condition |
| CD40LGCD40 ligand | Always | In 1 condition |
| H4C11H4 clustered histone 11 | Always | In 1 condition |
| MAP3K7mitogen-activated protein kinase kinase kinase 7 | Always | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Always | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Always | In 1 condition |
| RBL2RB transcriptional corepressor like 2 | Always | In 1 condition |
| RBMXRNA binding motif protein X-linked | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| TASP1taspase 1 | Always | In 1 condition |
| TCP1t-complex 1 | Always | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Always | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Very often (80–99%) | In 2 conditions |
| CHD1chromodomain helicase DNA binding protein 1 | Often (30–79%) | In 1 condition |
| DOCK7dedicator of cytokinesis 7 | Often (30–79%) | In 2 conditions |
| ELNelastin | Often (30–79%) | In 1 condition |
| H4C3H4 clustered histone 3 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| PCGF2polycomb group ring finger 2 | Often (30–79%) | In 1 condition |
| RPS23ribosomal protein S23 | Often (30–79%) | In 1 condition |
| SETD2SET domain containing 2, histone lysine methyltransferase | Often (30–79%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Often (30–79%) | In 1 condition |
| YY1YY1 transcription factor | Often (30–79%) | In 2 conditions |
| ANKRD17ankyrin repeat domain 17 | Sometimes (5–29%) | In 1 condition |
| ARXaristaless related homeobox | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| EDEM3ER degradation enhancing alpha-mannosidase like protein 3 | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HS2ST1heparan sulfate 2-O-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| KMT2Blysine methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| NRCAMneuronal cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| PLPBPpyridoxal phosphate binding protein | Sometimes (5–29%) | In 1 condition |
| PPP2CAprotein phosphatase 2 catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Sometimes (5–29%) | In 1 condition |
Show 10 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Not recorded | In 1 condition |
| FTSJ1FtsJ RNA 2'-O-methyltransferase 1 | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KMT2Elysine methyltransferase 2E (inactive) | Not recorded | In 1 condition |
| MAB21L2mab-21 like 2 | Not recorded | In 1 condition |
| MED13mediator complex subunit 13 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| SRCAPSnf2 related CREBBP activator protein | Not recorded | In 1 condition |
| TUBBtubulin beta class I | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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