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Trait

Small thenar eminence

Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb.

HPO HP:0001245

Summary

Also called
Decreased thenar eminence, Hypoplastic thenar eminences, Thenar hypoplasia, Thenar muscle hypoplasia
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

13 genes linked to Small thenar eminence

Changes in these genes cause rare conditions in which Small thenar eminence is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DHRS3dehydrogenase/reductase 3AlwaysIn 1 condition
HOXA13homeobox A13AlwaysIn 1 condition
EIF4A3eukaryotic translation initiation factor 4A3Very often (80–99%)In 2 conditions
SALL4spalt like transcription factor 4Very often (80–99%)In 2 conditions
TOP2BDNA topoisomerase II betaVery often (80–99%)In 1 condition
EMILIN1elastin microfibril interfacer 1Often (30–79%)In 1 condition
FGD4FYVE, RhoGEF and PH domain containing 4Often (30–79%)In 1 condition
LEF1lymphoid enhancer binding factor 1Often (30–79%)In 1 condition
RAD51CRAD51 paralog COften (30–79%)In 1 condition
RPS19ribosomal protein S19Often (30–79%)In 1 condition
TBX5T-box transcription factor 5Often (30–79%)In 1 condition
FBXW11F-box and WD repeat domain containing 11Sometimes (5–29%)In 1 condition
FGFR2fibroblast growth factor receptor 2Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the thenar eminence

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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