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Trait
Increased circulating prolactin concentration
The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy.
Summary
- Also called
- Hyperprolactinaemia, Hyperprolactinemia, Prolactin excess
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Get my Genome Test43 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Familial Isolated Pituitary Adenoma (FIPA / X-LAG)Reads 2 of these genesGPR101AIPAbout this report →
- Rhabdoid Tumour and SWI/SNF Tumour PredispositionReads 2 of these genesSMARCB1SMARCE1About this report →
- Carney Complex & Hereditary Adrenal Cushing SyndromeReads 2 of these genesPDE11APRKAR1AAbout this report →
- NeurofibromatosisReads 2 of these genesNF2SMARCB1About this report →
Show 39 more reports
- Pseudohypoparathyroidism & GNAS-Inactivation DisordersReads 2 of these genesPRKAR1AGNASAbout this report →
- BAP1 Tumour Predisposition SyndromeReads 1 of these genesBAP1About this report →
- CTNNB1 SyndromeReads 1 of these genesCTNNB1About this report →
- Curry-Jones Syndrome (Mosaic SMO Syndrome)Reads 1 of these genesSMOAbout this report →
- POLR3A-Related DisorderReads 1 of these genesPOLR3AAbout this report →
- Thyroid CancerReads 4 of these genesMEN1TRHRTSHBGNASAbout this report →
- Cowden Syndrome (PTEN hamartoma tumour syndrome)Reads 1 of these genesAKT1About this report →
- Fibrodysplasia Ossificans ProgressivaReads 1 of these genesGNASAbout this report →
- Nevoid Basal Cell Carcinoma (Gorlin) SyndromeReads 1 of these genesSUFUAbout this report →
- Coffin-Siris SyndromeReads 2 of these genesSMARCB1SMARCE1About this report →
- MedulloblastomaReads 1 of these genesSUFUAbout this report →
- Congenital HypothyroidismReads 2 of these genesTRHRTSHBAbout this report →
- MTOR Pathway Megalencephaly and Overgrowth DisordersReads 1 of these genesPIK3CAAbout this report →
- Growth Hormone Insensitivity & IGF-1 Axis DisordersReads 1 of these genesSTAT5BAbout this report →
- Basal Ganglia CalcificationReads 1 of these genesPDGFBAbout this report →
- Inherited Predisposition to Acute Myeloid LeukaemiaReads 1 of these genesTERTAbout this report →
- Malignant Endocrine NeoplasmReads 1 of these genesMEN1About this report →
- Familial Pulmonary FibrosisReads 1 of these genesTERTAbout this report →
- Kidney CancerReads 1 of these genesBAP1About this report →
- BH4 Deficiency & Monoamine Neurotransmitter DisordersReads 1 of these genesDDCAbout this report →
- HyperinsulinismReads 1 of these genesPMM2About this report →
- Usher SyndromeReads 1 of these genesCDH23About this report →
- Urinary and Renal System TumourReads 1 of these genesBAP1About this report →
- Ectodermal DysplasiasReads 1 of these genesLEF1About this report →
- Noonan SyndromeReads 1 of these genesBRAFAbout this report →
- Dyskeratosis CongenitaReads 1 of these genesTERTAbout this report →
- Syndromic Complex Neurodevelopmental DisorderReads 1 of these genesTRAF7About this report →
- Syndromic CraniosynostosisReads 1 of these genesSMOAbout this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 1 of these genesPOLR3AAbout this report →
- Non-Acquired Combined Pituitary Hormone DeficiencyReads 1 of these genesSMOAbout this report →
- VitreoretinopathyReads 1 of these genesCTNNB1About this report →
- Osteogenesis ImperfectaReads 1 of these genesPOLR3AAbout this report →
- Joubert Syndrome And Related DisordersReads 1 of these genesSUFUAbout this report →
- Intellectual DisabilityReads 2 of these genesCTNNB1SMARCB1About this report →
- Hypertrophic CardiomyopathyReads 1 of these genesBRAFAbout this report →
- Other Inherited LeukodystrophiesReads 1 of these genesPOLR3AAbout this report →
- Hearing Loss and DeafnessReads 1 of these genesCDH23About this report →
- Congenital Disorders of GlycosylationReads 1 of these genesPMM2About this report →
- Inherited Neurodegenerative DisordersReads 1 of these genesPOLR3AAbout this report →
Read the genes linked to Increased circulating prolactin concentration, and the rest of your genome, with one test.
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Get my Genome Test29 genes linked to Increased circulating prolactin concentration
Changes in these genes cause rare conditions in which Increased circulating prolactin concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PRLRprolactin receptor | Always | In 1 condition |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 2 conditions |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 3 conditions |
| AKT1AKT serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| MEN1menin 1 | Often (30–79%) | In 2 conditions |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Often (30–79%) | In 2 conditions |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Often (30–79%) | In 1 condition |
| PDE11Aphosphodiesterase 11A | Often (30–79%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Often (30–79%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Often (30–79%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Often (30–79%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Often (30–79%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Often (30–79%) | In 1 condition |
| TRHRthyrotropin releasing hormone receptor | Often (30–79%) | In 1 condition |
| TSHBthyroid stimulating hormone subunit beta | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Sometimes (5–29%) | In 1 condition |
| DDCdopa decarboxylase | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 3 conditions |
| LEF1lymphoid enhancer binding factor 1 | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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