Trait
Mild global developmental delay
A mild delay in the achievement of motor or mental milestones in the domains of development of a child.
Summary
- Also called
- Global developmental delay, mild
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Mild global developmental delay, and the rest of your genome, with one test.
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Get my Genome Test113 genes linked to Mild global developmental delay
Changes in these genes cause rare conditions in which Mild global developmental delay is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCA2ATP binding cassette subfamily A member 2 | Always | In 1 condition |
| ACTBactin beta | Always | In 2 conditions |
| AMTaminomethyltransferase | Always | In 1 condition |
| AP3B1adaptor related protein complex 3 subunit beta 1 | Always | In 1 condition |
| ATP5F1BATP synthase F1 subunit beta | Always | In 1 condition |
| CDC6cell division cycle 6 | Always | In 1 condition |
| CENATACcentrosomal AT-AC splicing factor | Always | In 1 condition |
| DHTKD1dehydrogenase E1 and transketolase domain containing 1 | Always | In 1 condition |
| EIF4A2eukaryotic translation initiation factor 4A2 | Always | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| ERMARDER membrane associated RNA degradation | Always | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Always | In 1 condition |
| GTF2H4general transcription factor IIH subunit 4 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| NFE2L2NFE2 like bZIP transcription factor 2 | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 1 condition |
| POLR1ARNA polymerase I subunit A | Always | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Always | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| RAI1retinoic acid induced 1 | Always | In 1 condition |
| SGSM3small G protein signaling modulator 3 | Always | In 1 condition |
| TMEM163transmembrane protein 163 | Always | In 1 condition |
| ATRATR checkpoint kinase | Very often (80–99%) | In 1 condition |
| ATRIPATR interacting protein | Very often (80–99%) | In 1 condition |
| CENPEcentromere protein E | Very often (80–99%) | In 1 condition |
| CEP152centrosomal protein 152 | Very often (80–99%) | In 1 condition |
| CEP295centrosomal protein 295 | Very often (80–99%) | In 1 condition |
| CEP63centrosomal protein 63 | Very often (80–99%) | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Very often (80–99%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Very often (80–99%) | In 1 condition |
| MCM4minichromosome maintenance complex component 4 | Very often (80–99%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Very often (80–99%) | In 1 condition |
| NINninein | Very often (80–99%) | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Very often (80–99%) | In 1 condition |
| NUP85nucleoporin 85 | Very often (80–99%) | In 1 condition |
| PCNTpericentrin | Very often (80–99%) | In 1 condition |
| PLK4polo like kinase 4 | Very often (80–99%) | In 1 condition |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Very often (80–99%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Very often (80–99%) | In 1 condition |
Show 73 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PTPMT1protein tyrosine phosphatase mitochondrial 1 | Very often (80–99%) | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Very often (80–99%) | In 2 conditions |
| TBX4T-box transcription factor 4 | Very often (80–99%) | In 1 condition |
| TRAIPTRAF interacting protein | Very often (80–99%) | In 1 condition |
| ZRSR2zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 | Very often (80–99%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Often (30–79%) | In 1 condition |
| ASPAaspartoacylase | Often (30–79%) | In 1 condition |
| CDH2cadherin 2 | Often (30–79%) | In 1 condition |
| DHRS3dehydrogenase/reductase 3 | Often (30–79%) | In 1 condition |
| DOLKdolichol kinase | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 2 conditions |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Often (30–79%) | In 1 condition |
| KCNK3potassium two pore domain channel subfamily K member 3 | Often (30–79%) | In 1 condition |
| KDM2Blysine demethylase 2B | Often (30–79%) | In 1 condition |
| MAP1Bmicrotubule associated protein 1B | Often (30–79%) | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Often (30–79%) | In 1 condition |
| PDP1pyruvate dehydrogenase phosphatase catalytic subunit 1 | Often (30–79%) | In 1 condition |
| PEPDpeptidase D | Often (30–79%) | In 1 condition |
| RPS6KC1ribosomal protein S6 kinase C1 | Often (30–79%) | In 1 condition |
| SF3B2splicing factor 3b subunit 2 | Often (30–79%) | In 1 condition |
| SNF8SNF8 subunit of ESCRT-II | Often (30–79%) | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Often (30–79%) | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Often (30–79%) | In 1 condition |
| WDR26WD repeat domain 26 | Often (30–79%) | In 1 condition |
| AASSaminoadipate-semialdehyde synthase | Sometimes (5–29%) | In 1 condition |
| ACAD8acyl-CoA dehydrogenase family member 8 | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| ALBalbumin | Sometimes (5–29%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Sometimes (5–29%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Sometimes (5–29%) | In 1 condition |
| CABP4calcium binding protein 4 | Sometimes (5–29%) | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Sometimes (5–29%) | In 2 conditions |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| CTSKcathepsin K | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| EYA1EYA transcriptional coactivator and phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| FTCDformimidoyltransferase cyclodeaminase | Sometimes (5–29%) | In 1 condition |
| FZD4frizzled class receptor 4 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| IARS1isoleucyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| KCNJ13potassium inwardly rectifying channel subfamily J member 13 | Sometimes (5–29%) | In 1 condition |
| LCA5lebercilin LCA5 | Sometimes (5–29%) | In 1 condition |
| LRATlecithin retinol acyltransferase | Sometimes (5–29%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Sometimes (5–29%) | In 2 conditions |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Sometimes (5–29%) | In 1 condition |
| PHKBphosphorylase kinase regulatory subunit beta | Sometimes (5–29%) | In 1 condition |
| PLCB4phospholipase C beta 4 | Sometimes (5–29%) | In 1 condition |
| PLP1proteolipid protein 1 | Sometimes (5–29%) | In 1 condition |
| POLRMTRNA polymerase mitochondrial | Sometimes (5–29%) | In 1 condition |
| PRPH2peripherin 2 | Sometimes (5–29%) | In 1 condition |
| PTF1Apancreas associated transcription factor 1a | Sometimes (5–29%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RPE65retinoid isomerohydrolase RPE65 | Sometimes (5–29%) | In 1 condition |
| RRAS2RAS related 2 | Sometimes (5–29%) | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Sometimes (5–29%) | In 1 condition |
| SIX1SIX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| SPATA7spermatogenesis associated 7 | Sometimes (5–29%) | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Sometimes (5–29%) | In 1 condition |
| TBX2T-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| TSPAN12tetraspanin 12 | Sometimes (5–29%) | In 1 condition |
| ZNF408zinc finger protein 408 | Sometimes (5–29%) | In 1 condition |
| RCC1regulator of chromosome condensation 1 | Rarely (1–4%) | In 1 condition |
| TCF12transcription factor 12 | Rarely (1–4%) | In 1 condition |
| NONOnon-POU domain containing octamer binding | Not recorded | In 1 condition |
| NSMCE3NSE3 component of SMC5/6 complex | Not recorded | In 1 condition |
| RNF168ring finger protein 168 | Not recorded | In 1 condition |
| ZNF462zinc finger protein 462 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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