Trait
Coma
The complete absence of wakefulness and consciousness, which is evident through a lack of response to any form of external stimuli.
Summary
- Also called
- Persistent vegetative state, Stupor, Unconsciousness
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test91 genes linked to Coma
Changes in these genes cause rare conditions in which Coma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB1ATP binding cassette subfamily B member 1 | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| IL18BPinterleukin 18 binding protein | Always | In 1 condition |
| LYRM7LYR motif containing 7 | Always | In 1 condition |
| MC2Rmelanocortin 2 receptor | Always | In 1 condition |
| MCCC1methylcrotonyl-CoA carboxylase subunit 1 | Always | In 1 condition |
| MMADHCmetabolism of cobalamin associated D | Always | In 1 condition |
| NAXENAD(P)HX epimerase | Always | In 1 condition |
| NDUFA2NADH:ubiquinone oxidoreductase subunit A2 | Always | In 1 condition |
| NIT1nitrilase 1 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SLC19A3solute carrier family 19 member 3 | Always | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Always | In 1 condition |
| APPamyloid beta precursor protein | Very often (80–99%) | In 2 conditions |
| HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 | Very often (80–99%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 1 condition |
| MMUTmethylmalonyl-CoA mutase | Very often (80–99%) | In 3 conditions |
| RANBP2RAN binding protein 2 | Very often (80–99%) | In 2 conditions |
| ACAT1acetyl-CoA acetyltransferase 1 | Often (30–79%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Often (30–79%) | In 2 conditions |
| CPT1Acarnitine palmitoyltransferase 1A | Often (30–79%) | In 2 conditions |
| CYC1cytochrome c1 | Often (30–79%) | In 1 condition |
| EIF2B5eukaryotic translation initiation factor 2B subunit epsilon | Often (30–79%) | In 1 condition |
| NAGSN-acetylglutamate synthase | Often (30–79%) | In 2 conditions |
| OTCornithine transcarbamylase | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| POLR3KRNA polymerase III subunit K | Often (30–79%) | In 1 condition |
| SLC22A5solute carrier family 22 member 5 | Often (30–79%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Often (30–79%) | In 1 condition |
| SQORsulfide quinone oxidoreductase | Often (30–79%) | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Often (30–79%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Sometimes (5–29%) | In 2 conditions |
| ACADMacyl-CoA dehydrogenase medium chain | Sometimes (5–29%) | In 2 conditions |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 2 conditions |
| CPT2carnitine palmitoyltransferase 2 | Sometimes (5–29%) | In 2 conditions |
| FBP1fructose-bisphosphatase 1 | Sometimes (5–29%) | In 2 conditions |
| FHfumarate hydratase | Sometimes (5–29%) | In 1 condition |
| GCKglucokinase | Sometimes (5–29%) | In 2 conditions |
Show 51 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Sometimes (5–29%) | In 1 condition |
| HLCSholocarboxylase synthetase | Sometimes (5–29%) | In 2 conditions |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Sometimes (5–29%) | In 2 conditions |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 1 condition |
| IVDisovaleryl-CoA dehydrogenase | Sometimes (5–29%) | In 2 conditions |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Sometimes (5–29%) | In 1 condition |
| KYNUkynureninase | Sometimes (5–29%) | In 1 condition |
| MEN1menin 1 | Sometimes (5–29%) | In 2 conditions |
| OXCT13-oxoacid CoA-transferase 1 | Sometimes (5–29%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Sometimes (5–29%) | In 1 condition |
| PRF1perforin 1 | Sometimes (5–29%) | In 2 conditions |
| PRRT2proline rich transmembrane protein 2 | Sometimes (5–29%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Sometimes (5–29%) | In 2 conditions |
| SLC25A15solute carrier family 25 member 15 | Sometimes (5–29%) | In 2 conditions |
| SLC25A20solute carrier family 25 member 20 | Sometimes (5–29%) | In 2 conditions |
| SLC7A7solute carrier family 7 member 7 | Sometimes (5–29%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STX11syntaxin 11 | Sometimes (5–29%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 1 condition |
| TICAM1TIR domain containing adaptor molecule 1 | Sometimes (5–29%) | In 1 condition |
| TLR3toll like receptor 3 | Sometimes (5–29%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Sometimes (5–29%) | In 1 condition |
| UNC13Dunc-13 homolog D | Sometimes (5–29%) | In 1 condition |
| UNC93B1unc-93B1 regulator of TLR signaling | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Rarely (1–4%) | In 2 conditions |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| CDKN1Bcyclin dependent kinase inhibitor 1B | Rarely (1–4%) | In 1 condition |
| CDKN2Bcyclin dependent kinase inhibitor 2B | Rarely (1–4%) | In 1 condition |
| CTNNB1catenin beta 1 | Rarely (1–4%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Rarely (1–4%) | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Rarely (1–4%) | In 1 condition |
| ASLargininosuccinate lyase | Not recorded | In 1 condition |
| ASS1argininosuccinate synthase 1 | Not recorded | In 1 condition |
| ATP7BATPase copper transporting beta | Not recorded | In 1 condition |
| BCKDHAbranched chain keto acid dehydrogenase E1 subunit alpha | Not recorded | In 1 condition |
| CFHcomplement factor H | Not recorded | In 1 condition |
| CFHR1complement factor H related 1 | Not recorded | In 1 condition |
| CFHR3complement factor H related 3 | Not recorded | In 1 condition |
| CPS1carbamoyl-phosphate synthase 1 | Not recorded | In 1 condition |
| GKglycerol kinase | Not recorded | In 1 condition |
| MCCC2methylcrotonyl-CoA carboxylase subunit 2 | Not recorded | In 1 condition |
| MMAAmetabolism of cobalamin associated A | Not recorded | In 1 condition |
| MMABmetabolism of cobalamin associated B | Not recorded | In 1 condition |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Not recorded | In 1 condition |
| PCCApropionyl-CoA carboxylase subunit alpha | Not recorded | In 1 condition |
| PCCBpropionyl-CoA carboxylase subunit beta | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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