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Trait
Low solidness and mass of the bones
Clinical name: Reduced bone mineral density
A reduction of bone mineral density, that is, of the amount of matter per cubic centimeter of bones.
Summary
- Also called
- Decreased bone mineral density, Decreased bone mineral density Z score
- Body system
- Abnormality of the musculoskeletal system
Low solidness and mass of the bonesHP:0004349
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Read the genes linked to Low solidness and mass of the bones, and the rest of your genome, with one test.
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Get my Genome Test135 genes linked to Low solidness and mass of the bones
Changes in these genes cause rare conditions in which Low solidness and mass of the bones is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BMP1bone morphogenetic protein 1 | Always | In 1 condition |
| CCDC134coiled-coil domain containing 134 | Always | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Always | In 2 conditions |
| GET4guided entry of tail-anchored proteins factor 4 | Always | In 1 condition |
| ITGAVintegrin subunit alpha V | Always | In 1 condition |
| LRP5LDL receptor related protein 5 | Always | In 2 conditions |
| MBTPS1membrane bound transcription factor peptidase, site 1 | Always | In 1 condition |
| NAE1NEDD8 activating enzyme E1 subunit 1 | Always | In 1 condition |
| NFATC2nuclear factor of activated T cells 2 | Always | In 1 condition |
| P4HBprolyl 4-hydroxylase subunit beta | Always | In 1 condition |
| PAPPA2pappalysin 2 | Always | In 1 condition |
| PHLDB1pleckstrin homology like domain family B member 1 | Always | In 1 condition |
| PUM1pumilio RNA binding family member 1 | Always | In 1 condition |
| SFRP4secreted frizzled related protein 4 | Always | In 1 condition |
| SPARCsecreted protein acidic and cysteine rich | Always | In 1 condition |
| UFSP2UFM1 specific peptidase 2 | Always | In 1 condition |
| WRNWRN RecQ like helicase | Always | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 1 condition |
| CYB5Acytochrome b5 type A | Very often (80–99%) | In 1 condition |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| CYP17A1cytochrome P450 family 17 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Very often (80–99%) | In 2 conditions |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| MMP13matrix metallopeptidase 13 | Very often (80–99%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Very often (80–99%) | In 1 condition |
| RETREG1reticulophagy regulator 1 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 1 condition |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TNFSF11TNF superfamily member 11 | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Very often (80–99%) | In 1 condition |
| WNK1WNK lysine deficient protein kinase 1 | Very often (80–99%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Often (30–79%) | In 1 condition |
| ANOS1anosmin 1 | Often (30–79%) | In 1 condition |
| BMP15bone morphogenetic protein 15 | Often (30–79%) | In 1 condition |
| BNC1basonuclin zinc finger protein 1 | Often (30–79%) | In 1 condition |
| CCDC141coiled-coil domain containing 141 | Often (30–79%) | In 1 condition |
Show 95 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CDKN1Bcyclin dependent kinase inhibitor 1B | Often (30–79%) | In 1 condition |
| CDKN2Bcyclin dependent kinase inhibitor 2B | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Often (30–79%) | In 1 condition |
| DCCDCC netrin 1 receptor | Often (30–79%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Often (30–79%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Often (30–79%) | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Often (30–79%) | In 1 condition |
| FEZF1FEZ family zinc finger 1 | Often (30–79%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Often (30–79%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FIGLAfolliculogenesis specific bHLH transcription factor | Often (30–79%) | In 1 condition |
| FLRT3fibronectin leucine rich transmembrane protein 3 | Often (30–79%) | In 1 condition |
| FSHRfollicle stimulating hormone receptor | Often (30–79%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 1 condition |
| HESX1HESX homeobox 1 | Often (30–79%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Often (30–79%) | In 1 condition |
| IL17RDinterleukin 17 receptor D | Often (30–79%) | In 1 condition |
| LEMD2LEM domain nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| MRPS22mitochondrial ribosomal protein S22 | Often (30–79%) | In 1 condition |
| MSH4mutS homolog 4 | Often (30–79%) | In 1 condition |
| NDNFneuron derived neurotrophic factor | Often (30–79%) | In 1 condition |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Often (30–79%) | In 1 condition |
| NUP107nucleoporin 107 | Often (30–79%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Often (30–79%) | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Often (30–79%) | In 1 condition |
| POLR3HRNA polymerase III subunit H | Often (30–79%) | In 1 condition |
| PROK2prokineticin 2 | Often (30–79%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Often (30–79%) | In 1 condition |
| PSMC3IPPSMC3 interacting protein | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| SEMA3Asemaphorin 3A | Often (30–79%) | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Often (30–79%) | In 1 condition |
| SLC34A3solute carrier family 34 member 3 | Often (30–79%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Often (30–79%) | In 1 condition |
| SPIDRscaffold protein involved in DNA repair | Often (30–79%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Often (30–79%) | In 1 condition |
| TACR3tachykinin receptor 3 | Often (30–79%) | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Often (30–79%) | In 1 condition |
| WDR11WD repeat domain 11 | Often (30–79%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Often (30–79%) | In 1 condition |
| ZSWIM7zinc finger SWIM-type containing 7 | Often (30–79%) | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Sometimes (5–29%) | In 1 condition |
| ARL6IP6ARF like GTPase 6 interacting protein 6 | Sometimes (5–29%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Sometimes (5–29%) | In 1 condition |
| CASRcalcium sensing receptor | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FANCAFA complementation group A | Sometimes (5–29%) | In 1 condition |
| FANCBFA complementation group B | Sometimes (5–29%) | In 1 condition |
| FANCCFA complementation group C | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Sometimes (5–29%) | In 1 condition |
| FANCEFA complementation group E | Sometimes (5–29%) | In 1 condition |
| FANCFFA complementation group F | Sometimes (5–29%) | In 1 condition |
| FANCGFA complementation group G | Sometimes (5–29%) | In 1 condition |
| FANCIFA complementation group I | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| FANCMFA complementation group M | Sometimes (5–29%) | In 1 condition |
| FXNfrataxin | Sometimes (5–29%) | In 1 condition |
| FZD4frizzled class receptor 4 | Sometimes (5–29%) | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Sometimes (5–29%) | In 1 condition |
| GLAgalactosidase alpha | Sometimes (5–29%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Sometimes (5–29%) | In 2 conditions |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Sometimes (5–29%) | In 1 condition |
| IGFALSinsulin like growth factor binding protein acid labile subunit | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| PEPDpeptidase D | Sometimes (5–29%) | In 1 condition |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| RAD51CRAD51 paralog C | Sometimes (5–29%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| TNFRSF11BTNF receptor superfamily member 11b | Sometimes (5–29%) | In 1 condition |
| TSPAN12tetraspanin 12 | Sometimes (5–29%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Sometimes (5–29%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Sometimes (5–29%) | In 1 condition |
| ZNF408zinc finger protein 408 | Sometimes (5–29%) | In 1 condition |
| FN1fibronectin 1 | Rarely (1–4%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Not recorded | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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