Trait
Cleft of the face
Clinical name: Tessier cleft
A congenital malformation with a cleft (gap or opening) in the face.
Summary
- Also called
- Facial cleft, Facial clefts, Tessier facial cleft
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Get my Genome Test16 genes linked to Cleft of the face
Changes in these genes cause rare conditions in which Cleft of the face is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| RIPK4receptor interacting serine/threonine kinase 4 | Always | In 1 condition |
| ALX1ALX homeobox 1 | Often (30–79%) | In 2 conditions |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Often (30–79%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Often (30–79%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Sometimes (5–29%) | In 1 condition |
| IFT80intraflagellar transport 80 | Sometimes (5–29%) | In 1 condition |
| POLR1BRNA polymerase I subunit B | Sometimes (5–29%) | In 1 condition |
| POLR1CRNA polymerase I and III subunit C | Sometimes (5–29%) | In 1 condition |
| POLR1DRNA polymerase I and III subunit D | Sometimes (5–29%) | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Sometimes (5–29%) | In 1 condition |
| WDR35WD repeat domain 35 | Sometimes (5–29%) | In 1 condition |
| COLEC10collectin subfamily member 10 | Not recorded | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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