Trait
Underdeveloped toenails
Clinical name: Hypoplastic toenails
Underdevelopment of the toenail.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Read the genes linked to Underdeveloped toenails, and the rest of your genome, with one test.
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Get my Genome Test66 genes linked to Underdeveloped toenails
Changes in these genes cause rare conditions in which Underdeveloped toenails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FTOFTO alpha-ketoglutarate dependent dioxygenase | Always | In 1 condition |
| PIGFphosphatidylinositol glycan anchor biosynthesis class F | Always | In 1 condition |
| POLR1ARNA polymerase I subunit A | Always | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| CTNNB1catenin beta 1 | Very often (80–99%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Very often (80–99%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Very often (80–99%) | In 2 conditions |
| EVC2EvC ciliary complex subunit 2 | Very often (80–99%) | In 2 conditions |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| GLI1GLI family zinc finger 1 | Very often (80–99%) | In 1 condition |
| MSX1msh homeobox 1 | Very often (80–99%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Very often (80–99%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Very often (80–99%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Very often (80–99%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Very often (80–99%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DPH1diphthamide biosynthesis 1 | Often (30–79%) | In 2 conditions |
| DPH2diphthamide biosynthesis 2 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| EOGTEGF domain specific O-linked N-acetylglucosamine transferase | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Often (30–79%) | In 1 condition |
| KDM1Alysine demethylase 1A | Often (30–79%) | In 2 conditions |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
Show 26 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC35D1solute carrier family 35 member D1 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ZIC3Zic family zinc finger 3 | Often (30–79%) | In 1 condition |
| AFF4ALF transcription elongation factor 4 | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Sometimes (5–29%) | In 1 condition |
| EIF5Aeukaryotic translation initiation factor 5A | Sometimes (5–29%) | In 1 condition |
| NOTCH1notch receptor 1 | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sometimes (5–29%) | In 1 condition |
| TBX3T-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TCTN3tectonic family member 3 | Sometimes (5–29%) | In 1 condition |
| TELO2telomere maintenance 2 | Sometimes (5–29%) | In 1 condition |
| WLSWnt ligand secretion mediator | Sometimes (5–29%) | In 1 condition |
| ZMYM2zinc finger MYM-type containing 2 | Sometimes (5–29%) | In 1 condition |
| DLL4delta like canonical Notch ligand 4 | Rarely (1–4%) | In 1 condition |
| EBF3EBF transcription factor 3 | Rarely (1–4%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Not recorded | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Not recorded | In 1 condition |
| NECTIN4nectin cell adhesion molecule 4 | Not recorded | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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