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Gene

ADK

adenosine kinase

Summary

Cytogenetic location
10q22.2
Coordinates
Chromosome 10: 74,151,221–74,709,290 (GRCh38)
Exons
11 exons across 558.1 kb
Protein
362 amino acids
Also known as
AK
MANE Select transcript
ENST00000539909.6NM_006721.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How ADK is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 10, with a bracket where ADK sits. ADK and 22 genes near it on chromosome 10, from 73,593,151 to 75,267,360.Chromosome 1010q22.2p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.373.6 Mb73.8 Mb74 Mb74.2 Mb74.4 Mb74.6 Mb74.8 Mb75 Mb75.2 MbUSP54: 73,497,538–73,626,117, reverse strandUSP54MYOZ1: 73,631,556–73,642,103, reverse strandMYOZ1SYNPO2L: 73,644,881–73,663,803, reverse strandSYNPO2LAGAP5: 73,674,276–73,698,109, reverse strandAGAP5SEC24C: 73,744,348–73,772,173, forward strandPOFUT4: 73,772,271–73,780,251, forward strandCHCHD1: 73,782,039–73,783,652, forward strandZSWIM8: 73,785,549–73,801,797, forward strandZSWIM8: 73,796,514–73,811,651, reverse strandNDST2: 73,801,740–73,811,963, reverse strandNDST2CAMK2G: 73,812,501–73,874,641, reverse strandCAMK2GPLAU: 73,909,177–73,917,501, forward strandPLAUVCL: 73,995,193–74,123,073, forward strandVCLAP3M1: 74,120,118–74,151,055, reverse strandAP3M1ADK: 74,151,221–74,709,290, forward strandADKKAT6B: 74,824,912–75,032,631, forward strandKAT6BDUSP29: 75,037,472–75,073,655, reverse strandDUSP29DUSP13A: 75,094,427–75,109,251, reverse strandDUSP13ADUSP13B: 75,094,432–75,106,499, reverse strandDUSP13BDUSP13B: 75,094,432–75,109,206, reverse strandDUSP13BSAMD8: 75,099,586–75,182,128, forward strandVDAC2: 75,209,978–75,231,463, forward strandVDAC2COMTD1: 75,230,309–75,236,088, reverse strandCOMTD1Diagram of ADK: 11 exons on the forward strand of chromosome 10Exon 1: 3 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 1: 74,151,221–74,151,343, 123 basesExon 2: 74,200,764–74,200,838, 75 basesExon 3: 74,224,538–74,224,591, 54 basesExon 4: 74,314,667–74,314,745, 79 basesExon 5: 74,394,141–74,394,313, 173 basesExon 6: 74,398,471–74,398,579, 109 basesExon 7: 74,525,256–74,525,426, 171 basesExon 8: 74,589,282–74,589,317, 36 basesExon 9: 74,600,379–74,600,493, 115 basesExon 10: 74,670,183–74,670,269, 87 basesExon 11: 74,708,321–74,709,290, 970 bases1246810115′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2 kb of the gene's 558.1 kb; 1,089 of those bases code for the protein.

    How a genome test reads ADK

    9

    positions in ADK where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 558.1 kb of ADK, introns included, not only the 2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ADK gene: adenosine kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/adk

    Vancouver

    Dante Labs. ADK gene: adenosine kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adk

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