Trait
Abnormal deposits of calcium in the brain
Clinical name: Cerebral calcification
The presence of calcium deposition within the cerebrum.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Abnormal deposits of calcium in the brain, and the rest of your genome, with one test.
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Get my Genome Test113 genes linked to Abnormal deposits of calcium in the brain
Changes in these genes cause rare conditions in which Abnormal deposits of calcium in the brain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADARadenosine deaminase RNA specific | Always | In 2 conditions |
| CA2carbonic anhydrase 2 | Always | In 2 conditions |
| COLGALT1collagen beta(1-O)galactosyltransferase 1 | Always | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Always | In 1 condition |
| CTC1CST telomere replication complex component 1 | Always | In 2 conditions |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Always | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Always | In 1 condition |
| IRF8interferon regulatory factor 8 | Always | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| KLklotho | Always | In 1 condition |
| NSMCE3NSE3 component of SMC5/6 complex | Always | In 1 condition |
| POT1protection of telomeres 1 | Always | In 1 condition |
| PPFIBP1PPFIB scaffold protein 1 | Always | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Always | In 1 condition |
| SLC4A4solute carrier family 4 member 4 | Always | In 1 condition |
| STAT2signal transducer and activator of transcription 2 | Always | In 1 condition |
| WWOXWW domain containing oxidoreductase | Always | In 1 condition |
| AP1S2adaptor related protein complex 1 subunit sigma 2 | Very often (80–99%) | In 2 conditions |
| ATP7AATPase copper transporting alpha | Very often (80–99%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 1 condition |
| CTNNB1catenin beta 1 | Very often (80–99%) | In 2 conditions |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Very often (80–99%) | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Very often (80–99%) | In 1 condition |
| OCLNoccludin | Very often (80–99%) | In 2 conditions |
| PTCH1patched 1 | Very often (80–99%) | In 1 condition |
| PTCH2patched 2 | Very often (80–99%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 1 condition |
| SNORD118small nucleolar RNA, C/D box 118 | Very often (80–99%) | In 2 conditions |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Very often (80–99%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Very often (80–99%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Very often (80–99%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Often (30–79%) | In 2 conditions |
| APPamyloid beta precursor protein | Often (30–79%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Often (30–79%) | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Often (30–79%) | In 1 condition |
Show 73 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CTSCcathepsin C | Often (30–79%) | In 1 condition |
| DENND5ADENN domain containing 5A | Often (30–79%) | In 1 condition |
| FAM20CFAM20C golgi associated secretory pathway kinase | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 2 conditions |
| LSM11LSM11, U7 small nuclear RNA associated | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 2 conditions |
| PDGFBplatelet derived growth factor subunit B | Often (30–79%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Often (30–79%) | In 2 conditions |
| RNASEH2Bribonuclease H2 subunit B | Often (30–79%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Often (30–79%) | In 2 conditions |
| RNU7-1RNA, U7 small nuclear 1 | Often (30–79%) | In 2 conditions |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Often (30–79%) | In 1 condition |
| SC5Dsterol-C5-desaturase | Often (30–79%) | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 2 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Often (30–79%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Sometimes (5–29%) | In 2 conditions |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Sometimes (5–29%) | In 2 conditions |
| AMER1APC membrane recruitment protein 1 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Sometimes (5–29%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Sometimes (5–29%) | In 2 conditions |
| ECM1extracellular matrix protein 1 | Sometimes (5–29%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Sometimes (5–29%) | In 2 conditions |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 2 conditions |
| GNASGNAS complex locus | Sometimes (5–29%) | In 2 conditions |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| KATNB1katanin regulatory subunit B1 | Sometimes (5–29%) | In 1 condition |
| MYMKmyomaker, myoblast fusion factor | Sometimes (5–29%) | In 1 condition |
| MYMXmyomixer, myoblast fusion factor | Sometimes (5–29%) | In 1 condition |
| MYO5Amyosin VA | Sometimes (5–29%) | In 1 condition |
| NDE1nudE neurodevelopment protein 1 | Sometimes (5–29%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 2 conditions |
| PEX1peroxisomal biogenesis factor 1 | Sometimes (5–29%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Sometimes (5–29%) | In 1 condition |
| RELNreelin | Sometimes (5–29%) | In 1 condition |
| RNASET2ribonuclease T2 | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 2 conditions |
| SLC26A2solute carrier family 26 member 2 | Sometimes (5–29%) | In 1 condition |
| SLC46A1solute carrier family 46 member 1 | Sometimes (5–29%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Sometimes (5–29%) | In 1 condition |
| SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1 | Sometimes (5–29%) | In 1 condition |
| TERCtelomerase RNA component | Sometimes (5–29%) | In 2 conditions |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 2 conditions |
| TINF2TERF1 interacting nuclear factor 2 | Sometimes (5–29%) | In 4 conditions |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| USP18ubiquitin specific peptidase 18 | Sometimes (5–29%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Sometimes (5–29%) | In 2 conditions |
| WRAP53WD repeat containing antisense to TP53 | Sometimes (5–29%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| CCM2CCM2 scaffold protein | Not recorded | In 1 condition |
| DAG1dystroglycan 1 | Not recorded | In 1 condition |
| IFNGinterferon gamma | Not recorded | In 1 condition |
| KRIT1KRIT1 ankyrin repeat containing | Not recorded | In 1 condition |
| MGPmatrix Gla protein | Not recorded | In 1 condition |
| PAHphenylalanine hydroxylase | Not recorded | In 1 condition |
| PDCD10programmed cell death 10 | Not recorded | In 1 condition |
| PTHparathyroid hormone | Not recorded | In 1 condition |
| QDPRquinoid dihydropteridine reductase | Not recorded | In 1 condition |
| TSC1TSC complex subunit 1 | Not recorded | In 1 condition |
| TSC2TSC complex subunit 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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