Trait
Retinal neovascularization
In ischemic retinal disease, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels. Ischemia invariably leads to the upregulation of Vascular Endothelial Growth Factor (VEGF) production. Most frequently the new vessels grow internal to the plane of the retina. However, intraretinal proliferation of new vessels can also occur.
Summary
- Also called
- Retinal vascular proliferation
Reference genomeGRCh38hg38
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Get my Genome Test11 genes linked to Retinal neovascularization
Changes in these genes cause rare conditions in which Retinal neovascularization is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LRRC32leucine rich repeat containing 32 | Always | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| FZD4frizzled class receptor 4 | Often (30–79%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Often (30–79%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Often (30–79%) | In 2 conditions |
| TSPAN12tetraspanin 12 | Often (30–79%) | In 1 condition |
| ZNF408zinc finger protein 408 | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 2 conditions |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| BEST1bestrophin 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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