Trait
Progressive spasticity
Spasticity that increases in degree with time.
Summary
- Also called
- Spasticity, progressive
Reference genomeGRCh38hg38
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Get my Genome Test20 genes linked to Progressive spasticity
Changes in these genes cause rare conditions in which Progressive spasticity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GALCgalactosylceramidase | Always | In 1 condition |
| HSPD1heat shock protein family D (Hsp60) member 1 | Always | In 1 condition |
| SELENOIselenoprotein I | Always | In 1 condition |
| TAF8TATA-box binding protein associated factor 8 | Always | In 1 condition |
| GLRX5glutaredoxin 5 | Very often (80–99%) | In 1 condition |
| SERAC1serine active site containing 1 | Very often (80–99%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Very often (80–99%) | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| MSL3MSL complex subunit 3 | Often (30–79%) | In 1 condition |
| NKX6-2NK6 homeobox 2 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Often (30–79%) | In 1 condition |
| TBCDtubulin folding cofactor D | Often (30–79%) | In 1 condition |
| ZSWIM6zinc finger SWIM-type containing 6 | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| DEGS1delta 4-desaturase, sphingolipid 1 | Not recorded | In 1 condition |
| GJC2gap junction protein gamma 2 | Not recorded | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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