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Trait

Tractional retinal detachment

A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes, in the absence of a full-thickness retinal defect.

HPO HP:0007917

Summary

Body system
Abnormality of the eye

7 genes linked to Tractional retinal detachment

Changes in these genes cause rare conditions in which Tractional retinal detachment is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ATOH7atonal bHLH transcription factor 7Often (30–79%)In 1 condition
CTNNB1catenin beta 1Often (30–79%)In 1 condition
FZD4frizzled class receptor 4Often (30–79%)In 3 conditions
LRP5LDL receptor related protein 5Often (30–79%)In 3 conditions
NDPnorrin cystine knot growth factor NDPOften (30–79%)In 3 conditions
TSPAN12tetraspanin 12Often (30–79%)In 2 conditions
ZNF408zinc finger protein 408Often (30–79%)In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Retinal detachment

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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