Gen
CTNNB1
catenin beta 1
- HGNC 2514(åbnes i en ny fane)
- Ensembl-gen ENSG00000168036(åbnes i en ny fane)
- NCBI Gene 1499(åbnes i en ny fane)
Oversigt
- Cytogenetisk placering
- 3p22.1
- Koordinater
- Kromosom 3: 41.199.505–41.240.443 (GRCh38)
- Exoner
- 15 exoner fordelt over 40,9 kb
- Protein
- 781 aminosyrer
- Også kendt som
- beta-catenin, armadillo
- Tidligere symboler
- CTNNB
- MANE Select-transkript
- ENST00000349496.11NM_001904.4
- Lokustype
- gene with protein product
- Meget høj
- Sikker
- Lav
- Meget lav
ReferencegenomGRCh38hg38
Positioner på gen- og variantsider følger dette valg i denne browser.
Læs CTNNB1 og resten af dit genom med én test.
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Bestil min Genome TestKurerede rapporter relevant for dette gen
Vitreoretinopati
- Vitreoretinal degeneration
- 2 GenCC-indsendere vurderer den som definitiv eller stærk
Bredere grupperinger
Intellektuel funktionsnedsættelse
Et af 233 gener, der er knyttet til det
- 4 GenCC-indsendere vurderer den som definitiv eller stærk
Sådan er CTNNB1 opbygget
- Kodende sekvens
- Utranslateret region
- Intron
- Transkriptionsretning
- Kendte sygdomsfremkaldende steder
- Regioner, som korte læsninger har svært ved
Eksoner i genets MANE Select-transkript (udgave v1.5), fra NCBI og EMBL-EBI, på referencegenomet GRCh38.
Kromosombånd fra UCSC's GRCh38-ideogram (2022-10-29).
Gener i nærheden fra Ensembl-udgivelse 116, på GRCh38.
Eksoner udgør 3,7 kb af genets 40,9 kb; 2.346 af disse baser koder for proteinet.
Sådan læser en genomtest CTNNB1
100
positioner i CTNNB1, hvor ClinVar klassificerer en ændring som patogen eller sandsynligvis patogen
Ingen af dem ligger i en region, som korte læsninger har svært ved.
En helgenomsanalyse dækker alle 40,9 kb af CTNNB1, inklusive introner, og ikke kun de 3,7 kb eksoner.
Træk knyttet til CTNNB1
Human Phenotype Ontology angiver disse som kendetegn ved de sjældne tilstande, CTNNB1 kan forårsage. Hvert træks side viser de andre gener, der er knyttet til det.
Abnormality of the nervous system
- Abnormal shape of hypothalamus
- Global developmental delay
- Intellectual disability
- Underdevelopment of part of brain called corpus callosum
- Intracranial cystic lesion
- Motor delay
- Poor speech
- Anxiety
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- Behavioral abnormality
- Delayed ability to sit
- Delayed ability to walk
- Difficulty sleeping
- Excessive daytime sleepiness
- Headache
- Irritability
- Loss of developmental milestones
- Panic attack
- Abnormal temper tantrums
- Aggressive behavior
- Autism spectrum disorder
- Delayed ability to crawl
- Delayed CNS myelination
- Difficulty finding words
- Echoing another person's speech
- Fluid-filled cyst in spinal cord
- Inability to speak
- Increased appetite
- Intellectual disability, mild
- Mild global developmental delay
- Pauses in breathing while sleeping
- Restlessness
- Rise in pressure inside skull
- Self-injurious behavior
- Self-mutilation
- Specific learning disability
- Spina bifida occulta
- Tethered cord
- Too much cerebrospinal fluid in the brain
- Ventriculomegaly
- Coma
- Epilepsy
- Medulloblastoma
Abnormality of head or neck
- Broad nasal tip
- Small head present at birth
- Abnormal dentition
- Abnormal facial shape
- Abnormal oral frenulum morphology
- Abnormally small head
- Cone shaped tooth
- Early eruption of teeth
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- Enlargement of facial bones
- Failure of development of between one and six teeth
- Increased thickness of skull cap
- Only one upper front tooth
- Bifid uvula
- Big calvaria
- Cleft of the face
- Cleft palate
- Delayed cranial suture closure
- Delayed eruption of teeth
- Flat back of skull
- Frontal bossing
- High, narrow palate
- Prominent forehead
- Submucous cleft hard palate
- Wide fontanelles
- Wide nasal bridge
- Bell's palsy
- Broad head shape
- Eye folds
- Flat face
- Little lower jaw
- Long philtrum
- Low hanging columella
- Receding chin
- Smooth philtrum
- Thin red part of the upper lip
- Underdeveloped tissue around nostril
- Abnormality of the bone of the forehead
- Abnormality of the nasal bone
- High palate
Abnormality of the eye
- Vitreoretinopathy
- Abnormal optic disc morphology
- Abnormal retinal pigmentation
- Abnormal visual field test
- Abnormality of the eye
- Bitemporal hemianopia
- Decreased clarity of vision
- Falciform retinal fold
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- Papilledema
- Progressive visual field defects
- Slow decrease in sharpness of vision
- Subretinal fluid
- Tractional retinal detachment
- Abnormally small eyeball
- Blindness
- Chorioretinal atrophy
- Close sighted
- Clouding of the lens of the eye
- Cross-eyed
- Epiretinal membrane
- Eye floaters
- Farsightedness
- Macular edema
- Marked vision impairment
- Optic atrophy
- Rhegmatogenous retinal detachment
- Exudative vitreoretinopathy
- Sudden decrease in vision
- Involuntary, rapid, rhythmic eye movements
- Retina degeneration
- Retinal detachment
- Retinal fold
- Retinal hole
Abnormality of the endocrine system
- Adrenocortical carcinoma
- Enlarged pituitary gland
- Hypopituitarism
- Neoplasm of the anterior pituitary
- Abnormal circulating dehydroepiandrosterone concentration
- Adrenocorticotropic hormone deficiency
- Central adrenal insufficiency
- Central diabetes insipidus
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- Decreased activity of gonads
- Elevated plasma aldosterone
- Elevated serum 11-deoxycortisol
- Hypogonadotropic hypogonadism
- Increased circulating androgen concentration
- Increased circulating androstenedione concentration
- Increased circulating cortisol level
- Increased circulating prolactin concentration
- Increased serum estradiol
- Low thyroid gland function due to abnormal pituitary gland
- Paradoxical increased cortisol secretion on dexamethasone suppression test
- Delayed puberty
Abnormality of the cardiovascular system
- Avascular peripheral retina
- High blood pressure
- Palpitations
- Retinal neovascularization
- Disruption of blood oxygen supply to brain
- Macular exudate
- Macular telangiectasia
- Narrowing of aorta
Vis 2 træk mere
Growth abnormality
- Mild short stature
- Increased body weight
- Obesity
- Weight loss
- Growth delay
- Proportionate short stature
- Severe short stature
- Small for gestational age
Vis 1 træk mere
Eksterne links
Genposter
Transkript
Protein
Hvor oplysningerne kommer fra
- HGNC: genets symbol, navn, andre symboler og placering.
- MANE Select v1.5, fra NCBI og EMBL-EBI: transkriptet, dets exoner og kodende sekvens.
- GenCC og ClinGen, udgivet 2026-10-16: hvilke sygdomme genet er knyttet til, og hvor stærkt.
- ACMG-listen over sekundære fund, SF v3.2.
- ClinVar og GIAB-stratifikationerne: kendte sygdomsfremkaldende positioner og de regioner, som korte læsninger har svært ved at aflæse.
- Human Phenotype Ontology, version 2026-09-01: de træk, der er knyttet til genet. Læs mere på hpo.jax.org.
- Dataudgivelse 2026.10.16-c6eea6bf.
Citér denne side
Dante Labs. (u.d.). CTNNB1-genet: catenin beta 1. Hentet 17. oktober 2026, fra https://dantelabs.com/da/genes/ctnnb1
Dante Labs. CTNNB1-genet: catenin beta 1 [Internet]. [citeret 17. oktober 2026]. Tilgængelig fra: https://dantelabs.com/da/genes/ctnnb1
Én test. Svar for hele livet.
Fra 449 $Gratis forsendelse · Resultater på 6–8 uger