Trait
Increased appetite
Clinical name: Polyphagia
A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat.
Summary
- Also called
- Voracious appetite, Hyperphagia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test81 genes linked to Increased appetite
Changes in these genes cause rare conditions in which Increased appetite is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADCY3adenylate cyclase 3 | Always | In 1 condition |
| ATP5F1BATP synthase F1 subunit beta | Always | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Always | In 1 condition |
| FAM177A1family with sequence similarity 177 member A1 | Always | In 1 condition |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Always | In 1 condition |
| IFT74intraflagellar transport 74 | Always | In 1 condition |
| LEPleptin | Always | In 2 conditions |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| MN1MN1 proto-oncogene, transcriptional regulator | Always | In 1 condition |
| NTRK2neurotrophic receptor tyrosine kinase 2 | Always | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Always | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| LEPRleptin receptor | Very often (80–99%) | In 2 conditions |
| MAGEL2MAGE family member L2 | Very often (80–99%) | In 7 conditions |
| MC4Rmelanocortin 4 receptor | Very often (80–99%) | In 2 conditions |
| NDNnecdin, MAGE family member | Very often (80–99%) | In 4 conditions |
| OCA2OCA2 melanosomal transmembrane protein | Very often (80–99%) | In 3 conditions |
| PCSK1proprotein convertase subtilisin/kexin type 1 | Very often (80–99%) | In 1 condition |
| POMCproopiomelanocortin | Very often (80–99%) | In 2 conditions |
| PREPLprolyl endopeptidase like | Very often (80–99%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Very often (80–99%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Very often (80–99%) | In 3 conditions |
| SLC3A1solute carrier family 3 member 1 | Very often (80–99%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Very often (80–99%) | In 5 conditions |
| ADNPactivity dependent neuroprotector homeobox | Often (30–79%) | In 2 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Often (30–79%) | In 1 condition |
| ATP10AATPase phospholipid transporting 10A (putative) | Often (30–79%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Often (30–79%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| GNASGNAS complex locus | Often (30–79%) | In 2 conditions |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 2 conditions |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| MKRN3makorin ring finger protein 3 | Often (30–79%) | In 1 condition |
| MYT1Lmyelin transcription factor 1 like | Often (30–79%) | In 2 conditions |
| NPAP1nuclear pore associated protein 1 | Often (30–79%) | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Often (30–79%) | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Often (30–79%) | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Often (30–79%) | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Often (30–79%) | In 1 condition |
Show 41 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit | Often (30–79%) | In 1 condition |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Often (30–79%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 1 condition |
| YY1YY1 transcription factor | Often (30–79%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| CASZ1castor zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Sometimes (5–29%) | In 1 condition |
| HNF1AHNF1 homeobox A | Sometimes (5–29%) | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| HTThuntingtin | Sometimes (5–29%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Sometimes (5–29%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Sometimes (5–29%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Sometimes (5–29%) | In 1 condition |
| MMP23Bmatrix metallopeptidase 23B | Sometimes (5–29%) | In 1 condition |
| PDPNpodoplanin | Sometimes (5–29%) | In 1 condition |
| PRDM16PR/SET domain 16 | Sometimes (5–29%) | In 1 condition |
| PRKCZprotein kinase C zeta | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SKISKI proto-oncogene | Sometimes (5–29%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| SRRM2serine/arginine repetitive matrix 2 | Sometimes (5–29%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Sometimes (5–29%) | In 1 condition |
| UCP2uncoupling protein 2 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZSCAN10zinc finger and SCAN domain containing 10 | Sometimes (5–29%) | In 1 condition |
| ACBD6acyl-CoA binding domain containing 6 | Rarely (1–4%) | In 1 condition |
| AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2 | Not recorded | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Not recorded | In 1 condition |
| GPR101G protein-coupled receptor 101 | Not recorded | In 1 condition |
| GRNgranulin precursor | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| MAPTmicrotubule associated protein tau | Not recorded | In 2 conditions |
| PSEN1presenilin 1 | Not recorded | In 2 conditions |
| SETD2SET domain containing 2, histone lysine methyltransferase | Not recorded | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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