Trait
More active than typical
Clinical name: Hyperactivity
Hyperactivity is a condition characterized by constant and unusually high levels of activity, even in situations where it is deemed inappropriate.
Summary
- Also called
- Hyperactive behavior, Hyperactive behaviour, Hyperkinetic disorder
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to More active than typical, and the rest of your genome, with one test.
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Get my Genome Test232 genes linked to More active than typical
Changes in these genes cause rare conditions in which More active than typical is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AASSaminoadipate-semialdehyde synthase | Always | In 2 conditions |
| AGO1argonaute RISC component 1 | Always | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Always | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Always | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Always | In 1 condition |
| AQP4aquaporin 4 | Always | In 1 condition |
| ARID1AAT-rich interaction domain 1A | Always | In 2 conditions |
| ARID2AT-rich interaction domain 2 | Always | In 2 conditions |
| BBS2Bardet-Biedl syndrome 2 | Always | In 1 condition |
| CC2D1Acoiled-coil and C2 domain containing 1A | Always | In 1 condition |
| DPYSdihydropyrimidinase | Always | In 1 condition |
| FAM177A1family with sequence similarity 177 member A1 | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| GNB5G protein subunit beta 5 | Always | In 1 condition |
| GON4Lgon-4 like | Always | In 1 condition |
| IGF1insulin like growth factor 1 | Always | In 2 conditions |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| KDM5Clysine demethylase 5C | Always | In 1 condition |
| MANBAmannosidase beta | Always | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Always | In 1 condition |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Always | In 1 condition |
| MID2midline 2 | Always | In 1 condition |
| MMADHCmetabolism of cobalamin associated D | Always | In 1 condition |
| MSL2MSL complex subunit 2 | Always | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Always | In 1 condition |
| PDCD6IPprogrammed cell death 6 interacting protein | Always | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Always | In 2 conditions |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Always | In 1 condition |
| SLC6A19solute carrier family 6 member 19 | Always | In 1 condition |
| TSHRthyroid stimulating hormone receptor | Always | In 3 conditions |
| TTI2TELO2 interacting protein 2 | Always | In 2 conditions |
| UGGT1UDP-glucose glycoprotein glucosyltransferase 1 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 2 conditions |
| CNKSR2connector enhancer of kinase suppressor of Ras 2 | Very often (80–99%) | In 1 condition |
| CUL4Bcullin 4B | Very often (80–99%) | In 2 conditions |
| MECP2methyl-CpG binding protein 2 | Very often (80–99%) | In 1 condition |
| PTCH1patched 1 | Very often (80–99%) | In 1 condition |
| AFF2ALF transcription elongation factor 2 | Often (30–79%) | In 2 conditions |
| ANK3ankyrin 3 | Often (30–79%) | In 2 conditions |
Show 192 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| AP1G1adaptor related protein complex 1 subunit gamma 1 | Often (30–79%) | In 1 condition |
| AP2M1adaptor related protein complex 2 subunit mu 1 | Often (30–79%) | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Often (30–79%) | In 1 condition |
| ASPMassembly factor for spindle microtubules | Often (30–79%) | In 1 condition |
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Often (30–79%) | In 1 condition |
| ATP6V0A1ATPase H+ transporting V0 subunit a1 | Often (30–79%) | In 1 condition |
| ATP9AATPase phospholipid transporting 9A | Often (30–79%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Often (30–79%) | In 1 condition |
| CHD2chromodomain helicase DNA binding protein 2 | Often (30–79%) | In 2 conditions |
| CUL3cullin 3 | Often (30–79%) | In 1 condition |
| CUX2cut like homeobox 2 | Often (30–79%) | In 1 condition |
| DDX3XDEAD-box helicase 3 X-linked | Often (30–79%) | In 2 conditions |
| DENND5ADENN domain containing 5A | Often (30–79%) | In 1 condition |
| DNM1dynamin 1 | Often (30–79%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Often (30–79%) | In 1 condition |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 3 conditions |
| FBXO11F-box protein 11 | Often (30–79%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Often (30–79%) | In 1 condition |
| FRMPD4FERM and PDZ domain containing 4 | Often (30–79%) | In 1 condition |
| FZR1fizzy and cell division cycle 20 related 1 | Often (30–79%) | In 1 condition |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Often (30–79%) | In 2 conditions |
| GATAD2BGATA zinc finger domain containing 2B | Often (30–79%) | In 2 conditions |
| GLRA2glycine receptor alpha 2 | Often (30–79%) | In 1 condition |
| GNSglucosamine (N-acetyl)-6-sulfatase | Often (30–79%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| IFNGinterferon gamma | Often (30–79%) | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Often (30–79%) | In 2 conditions |
| KCNK9potassium two pore domain channel subfamily K member 9 | Often (30–79%) | In 1 condition |
| KLHL20kelch like family member 20 | Often (30–79%) | In 1 condition |
| KMT2Alysine methyltransferase 2A | Often (30–79%) | In 2 conditions |
| LNPKlunapark, ER junction formation factor | Often (30–79%) | In 1 condition |
| MAPK10mitogen-activated protein kinase 10 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 1 condition |
| NAV3neuron navigator 3 | Often (30–79%) | In 1 condition |
| NEXMIFneurite extension and migration factor | Often (30–79%) | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Often (30–79%) | In 2 conditions |
| NTNG2netrin G2 | Often (30–79%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Often (30–79%) | In 2 conditions |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 2 conditions |
| PUS7pseudouridine synthase 7 | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 2 conditions |
| RNU2-2RNA, U2 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Often (30–79%) | In 1 condition |
| RUSC2RUN and SH3 domain containing 2 | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 2 conditions |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Often (30–79%) | In 1 condition |
| SHROOM4shroom family member 4 | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Often (30–79%) | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Often (30–79%) | In 1 condition |
| SMARCC2SWI/SNF related BAF chromatin remodeling complex subunit C2 | Often (30–79%) | In 2 conditions |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Often (30–79%) | In 1 condition |
| THRBthyroid hormone receptor beta | Often (30–79%) | In 1 condition |
| TRAPPC9trafficking protein particle complex subunit 9 | Often (30–79%) | In 1 condition |
| TSC1TSC complex subunit 1 | Often (30–79%) | In 1 condition |
| TSC2TSC complex subunit 2 | Often (30–79%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 3 conditions |
| UBE3Cubiquitin protein ligase E3C | Often (30–79%) | In 1 condition |
| WBP4WW domain binding protein 4 | Often (30–79%) | In 1 condition |
| YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | Often (30–79%) | In 1 condition |
| ZSWIM6zinc finger SWIM-type containing 6 | Often (30–79%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| ADAT3adenosine deaminase tRNA specific 3 | Sometimes (5–29%) | In 2 conditions |
| ARID1BAT-rich interaction domain 1B | Sometimes (5–29%) | In 1 condition |
| ARPC4actin related protein 2/3 complex subunit 4 | Sometimes (5–29%) | In 1 condition |
| ARXaristaless related homeobox | Sometimes (5–29%) | In 1 condition |
| ATP10AATPase phospholipid transporting 10A (putative) | Sometimes (5–29%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Sometimes (5–29%) | In 2 conditions |
| BAIAP2BAR/IMD domain containing adaptor protein 2 | Sometimes (5–29%) | In 1 condition |
| BCAP31B cell receptor associated protein 31 | Sometimes (5–29%) | In 1 condition |
| BCKDKbranched chain keto acid dehydrogenase kinase | Sometimes (5–29%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Sometimes (5–29%) | In 2 conditions |
| CACNA1Ecalcium voltage-gated channel subunit alpha1 E | Sometimes (5–29%) | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Sometimes (5–29%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Sometimes (5–29%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| CHKAcholine kinase alpha | Sometimes (5–29%) | In 1 condition |
| CICcapicua transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| CLCN3Cl-/H+ antiporter 3 | Sometimes (5–29%) | In 1 condition |
| CLCN4Cl-/H+ antiporter 4 | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Sometimes (5–29%) | In 2 conditions |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 3 conditions |
| DMPKDM1 protein kinase | Sometimes (5–29%) | In 1 condition |
| DMXL2Dmx like 2 | Sometimes (5–29%) | In 1 condition |
| DPF2double PHD fingers 2 | Sometimes (5–29%) | In 2 conditions |
| DPP6dipeptidyl peptidase like 6 | Sometimes (5–29%) | In 1 condition |
| DYMdymeclin | Sometimes (5–29%) | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Sometimes (5–29%) | In 2 conditions |
| FOXP2forkhead box P2 | Sometimes (5–29%) | In 1 condition |
| GAMTguanidinoacetate N-methyltransferase | Sometimes (5–29%) | In 1 condition |
| GNAO1G protein subunit alpha o1 | Sometimes (5–29%) | In 1 condition |
| GRIA1glutamate ionotropic receptor AMPA type subunit 1 | Sometimes (5–29%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| GRM7glutamate metabotropic receptor 7 | Sometimes (5–29%) | In 1 condition |
| HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| KCNC2potassium voltage-gated channel subfamily C member 2 | Sometimes (5–29%) | In 1 condition |
| KDM6Blysine demethylase 6B | Sometimes (5–29%) | In 1 condition |
| KIF15kinesin family member 15 | Sometimes (5–29%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Sometimes (5–29%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Sometimes (5–29%) | In 1 condition |
| MICU1mitochondrial calcium uptake 1 | Sometimes (5–29%) | In 1 condition |
| MTORmechanistic target of rapamycin kinase | Sometimes (5–29%) | In 1 condition |
| NEUROD2neuronal differentiation 2 | Sometimes (5–29%) | In 1 condition |
| NFIXnuclear factor I X | Sometimes (5–29%) | In 1 condition |
| PAHphenylalanine hydroxylase | Sometimes (5–29%) | In 2 conditions |
| PAK3p21 (RAC1) activated kinase 3 | Sometimes (5–29%) | In 1 condition |
| PANK2pantothenate kinase 2 | Sometimes (5–29%) | In 1 condition |
| PCDH19protocadherin 19 | Sometimes (5–29%) | In 1 condition |
| PIDD1p53-induced death domain protein 1 | Sometimes (5–29%) | In 1 condition |
| PIGPphosphatidylinositol glycan anchor biosynthesis class P | Sometimes (5–29%) | In 1 condition |
| PIGQphosphatidylinositol glycan anchor biosynthesis class Q | Sometimes (5–29%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Sometimes (5–29%) | In 2 conditions |
| PNPpurine nucleoside phosphorylase | Sometimes (5–29%) | In 1 condition |
| PPP2R1Aprotein phosphatase 2 scaffold subunit Aalpha | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Sometimes (5–29%) | In 1 condition |
| SIK1salt inducible kinase 1 | Sometimes (5–29%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Sometimes (5–29%) | In 2 conditions |
| SLC25A13solute carrier family 25 member 13 | Sometimes (5–29%) | In 1 condition |
| SLC25A22solute carrier family 25 member 22 | Sometimes (5–29%) | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC4A10solute carrier family 4 member 10 | Sometimes (5–29%) | In 1 condition |
| SLITRK2SLIT and NTRK like family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| SMARCA4SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | Sometimes (5–29%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Sometimes (5–29%) | In 1 condition |
| SMARCD1SWI/SNF related BAF chromatin remodeling complex subunit D1 | Sometimes (5–29%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Sometimes (5–29%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 1 condition |
| SOX11SRY-box transcription factor 11 | Sometimes (5–29%) | In 1 condition |
| SOX4SRY-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| SPRED1sprouty related EVH1 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Sometimes (5–29%) | In 1 condition |
| STEEP1STING1 ER exit protein 1 | Sometimes (5–29%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Sometimes (5–29%) | In 1 condition |
| TMEM147transmembrane protein 147 | Sometimes (5–29%) | In 1 condition |
| TMEM222transmembrane protein 222 | Sometimes (5–29%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Sometimes (5–29%) | In 1 condition |
| TRIP12thyroid hormone receptor interactor 12 | Sometimes (5–29%) | In 1 condition |
| TTI1TELO2 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| UBTFupstream binding transcription factor | Sometimes (5–29%) | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Sometimes (5–29%) | In 1 condition |
| WDR62WD repeat domain 62 | Sometimes (5–29%) | In 1 condition |
| YME1L1YME1 like 1 ATPase | Sometimes (5–29%) | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Rarely (1–4%) | In 1 condition |
| H3-3AH3.3 histone A | Rarely (1–4%) | In 1 condition |
| HALhistidine ammonia-lyase | Rarely (1–4%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Rarely (1–4%) | In 1 condition |
| ACY1aminoacylase 1 | Not recorded | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Not recorded | In 1 condition |
| ADSLadenylosuccinate lyase | Not recorded | In 1 condition |
| ALDH5A1aldehyde dehydrogenase 5 family member A1 | Not recorded | In 1 condition |
| ARG1arginase 1 | Not recorded | In 1 condition |
| ATRATR checkpoint kinase | Not recorded | In 1 condition |
| ATRXATRX chromatin remodeler | Not recorded | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Not recorded | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Not recorded | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Not recorded | In 1 condition |
| DPYDdihydropyrimidine dehydrogenase | Not recorded | In 1 condition |
| DRD4dopamine receptor D4 | Not recorded | In 1 condition |
| DRD5dopamine receptor D5 | Not recorded | In 1 condition |
| FLCNfolliculin | Not recorded | In 1 condition |
| GLDCglycine decarboxylase | Not recorded | In 1 condition |
| HDAC4histone deacetylase 4 | Not recorded | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Not recorded | In 1 condition |
| IL1RAPL1interleukin 1 receptor accessory protein like 1 | Not recorded | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Not recorded | In 1 condition |
| NBNnibrin | Not recorded | In 1 condition |
| OPHN1oligophrenin 1 | Not recorded | In 1 condition |
| PDE4Dphosphodiesterase 4D | Not recorded | In 1 condition |
| PRODHproline dehydrogenase 1 | Not recorded | In 1 condition |
| RAB39BRAB39B, member RAS oncogene family | Not recorded | In 1 condition |
| SATB2SATB homeobox 2 | Not recorded | In 1 condition |
| SGSHN-sulfoglucosamine sulfohydrolase | Not recorded | In 1 condition |
| SPRsepiapterin reductase | Not recorded | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Not recorded | In 1 condition |
| TCF20transcription factor 20 | Not recorded | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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