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Gene

KCNC2

potassium voltage-gated channel subfamily C member 2

Summary

Cytogenetic location
12q21.1
Coordinates
Chromosome 12: 75,040,078–75,209,839 (GRCh38)
Exons
5 exons across 169.8 kb
Protein
638 amino acids
Also known as
Kv3.2
MANE Select transcript
ENST00000549446.6NM_139137.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How KCNC2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where KCNC2 sits. KCNC2 and 5 genes near it on chromosome 12, from 74,624,959 to 75,624,958.Chromosome 1212q21.1p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3374.8 Mb75 Mb75.2 Mb75.4 Mb75.6 MbKCNC2: 75,040,078–75,209,839, reverse strandKCNC2CAPS2: 75,275,979–75,390,950, reverse strandCAPS2GLIPR1L1: 75,334,670–75,370,560, forward strandGLIPR1L1GLIPR1L2: 75,391,049–75,432,692, forward strandGLIPR1L2GLIPR1: 75,480,752–75,503,863, forward strandGLIPR1KRR1: 75,490,863–75,511,676, reverse strandKRR1Diagram of KCNC2: 5 exons on the reverse strand of chromosome 12Exon 3: 5 known disease-causing sitesExon 2: 1 known disease-causing siteExon 5: 75,040,078–75,043,241, 3,164 basesExon 4: 75,048,153–75,048,317, 165 basesExon 3: 75,050,390–75,051,317, 928 basesExon 2: 75,207,297–75,208,002, 706 basesExon 1: 75,209,207–75,209,839, 633 bases515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.6 kb of the gene's 169.8 kb; 1,917 of those bases code for the protein.

    How a genome test reads KCNC2

    6

    positions in KCNC2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 169.8 kb of KCNC2, introns included, not only the 5.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KCNC2 gene: potassium voltage-gated channel subfamily C member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnc2

    Vancouver

    Dante Labs. KCNC2 gene: potassium voltage-gated channel subfamily C member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnc2

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