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Gene

MANBA

mannosidase beta

Summary

Cytogenetic location
4q24
Coordinates
Chromosome 4: 102,630,770–102,760,968 (GRCh38)
Exons
17 exons across 130.2 kb
Protein
879 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000647097.2NM_005908.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Alpha-Mannosidosis and Other Glycoproteinoses

    • Beta-mannosidosisAutosomal recessive

      Variable intellectual disability, hearing loss and behavioural problems, caused by MANBA variants.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

Broader groupings

  • Lysosomal Storage Disease

    • Lysosomal storage disease (other and unspecified types)

      One of 59 genes linked to it

      Covers lysosomal storage diseases without a dedicated report, such as Farber disease and other ASAH1-related disorders, prosaposin (PSAP) deficiencies, multiple sulfatase deficiency, mucopolysaccharidosis types IX and X, and Dorfman-Chanarin disease; inheritance varies by subtype, most often autosomal recessive.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How MANBA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where MANBA sits. MANBA and 8 genes near it on chromosome 4, from 102,195,869 to 103,195,868.Chromosome 44q24p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2102.2 Mb102.4 Mb102.6 Mb102.8 Mb103 MbSLC39A8: 102,251,037–102,431,258, reverse strandSLC39A8NFKB1: 102,500,911–102,617,302, forward strandNFKB1MANBA: 102,630,770–102,760,968, reverse strandMANBAUBE2D3: 102,793,516–102,869,287, reverse strandUBE2D3CISD2: 102,868,738–102,903,259, forward strandCISD2SLC9B1: 102,870,501–103,019,793, reverse strandSLC9B1SLC9B2: 103,019,868–103,085,829, reverse strandSLC9B2BDH2: 103,077,592–103,099,885, reverse strandBDH2CENPE: 103,105,349–103,198,463, reverse strandCENPEDiagram of MANBA: 17 exons on the reverse strand of chromosome 4Exon 16: 7 known disease-causing sitesExon 15: 6 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 7 known disease-causing sitesExon 12: 12 known disease-causing sitesExon 11: 6 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 6: 8 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 17: 102,630,770–102,632,281, 1,512 basesExon 16: 102,634,788–102,635,045, 258 basesExon 15: 102,635,865–102,636,007, 143 basesExon 14: 102,639,713–102,639,857, 145 basesExon 13: 102,650,537–102,650,701, 165 basesExon 12: 102,657,682–102,657,900, 219 basesExon 11: 102,664,685–102,664,852, 168 basesExon 10: 102,668,963–102,669,049, 87 basesExon 9: 102,671,281–102,671,398, 118 basesExon 8: 102,673,919–102,674,070, 152 basesExon 7: 102,689,574–102,689,684, 111 basesExon 6: 102,690,596–102,690,771, 176 basesExon 5: 102,714,438–102,714,561, 124 basesExon 4: 102,722,871–102,723,041, 171 basesExon 3: 102,723,862–102,723,967, 106 basesExon 2: 102,726,589–102,726,683, 95 basesExon 1: 102,760,718–102,760,968, 251 bases1716141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4 kb of the gene's 130.2 kb; 2,640 of those bases code for the protein.

How a genome test reads MANBA

101

positions in MANBA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 130.2 kb of MANBA, introns included, not only the 4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MANBA gene: mannosidase beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/manba

Vancouver

Dante Labs. MANBA gene: mannosidase beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/manba

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