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Gene

SLC25A22

solute carrier family 25 member 22

Summary

Cytogenetic location
11p15.5
Coordinates
Chromosome 11: 790,475–798,281 (GRCh38)
Exons
10 exons across 7.8 kb
Protein
323 amino acids
Also known as
GC1, FLJ13044, NET44, EIEE3, GC-1
MANE Select transcript
ENST00000628067.3NM_001191061.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How SLC25A22 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 11, with a bracket where SLC25A22 sits. SLC25A22 and 43 genes near it on chromosome 11, from 294,378 to 1,294,377.Chromosome 1111p15.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q250.4 Mb0.6 Mb0.8 Mb1 Mb1.2 MbPGGHG: 289,078–297,510, forward strandIFITM5: 298,200–299,533, reverse strandIFITM2: 303,655–309,410, forward strandIFITM2: 308,408–315,272, forward strandIFITM3: 309,010–329,475, reverse strandIFITM3IFITM1: 309,997–315,275, forward strandIFITM1B4GALNT4: 369,457–382,117, forward strandB4GALNT4PKP3: 392,574–404,908, forward strandPKP3SIGIRR: 405,711–417,473, reverse strandSIGIRRANO9: 417,921–442,072, reverse strandANO9PTDSS2: 448,268–501,142, forward strandPTDSS2RNH1: 494,510–507,395, reverse strandRNH1HRAS: 532,242–537,343, reverse strandHRASLRRC56: 536,841–554,925, forward strandLRRC56LMNTD2: 554,850–560,743, reverse strandLMNTD2RASSF7: 560,207–564,067, forward strandRASSF7PHRF1: 576,170–612,263, forward strandIRF7: 612,551–615,983, reverse strandIRF7CDHR5: 616,405–626,078, reverse strandCDHR5SCT: 626,309–627,236, reverse strandSCTDRD4: 637,269–640,706, forward strandDRD4DEAF1: 644,220–707,118, reverse strandDEAF1EPS8L2: 694,438–727,729, forward strandEPS8L2TMEM80: 695,011–705,028, forward strandTMEM80TALDO1: 747,399–765,035, forward strandGATD1: 767,061–777,507, reverse strandCEND1: 785,900–790,113, reverse strandCEND1SLC25A22: 790,475–798,281, reverse strandSLC25A22PANO1: 797,511–799,190, forward strandPANO1PIDD1: 798,938–809,753, reverse strandRPLP2: 799,414–812,891, forward strand: 803,398–804,419, reverse strandPNPLA2: 818,907–825,573, forward strandCRACR2B: 826,137–831,993, forward strandCD151: 832,702–839,831, forward strandPOLR2L: 837,356–842,727, reverse strandTSPAN4: 840,686–867,120, forward strandTSPAN4CHID1: 866,873–915,579, reverse strandCHID1AP2A2: 924,881–1,012,245, forward strandAP2A2MUC6: 1,012,823–1,036,718, reverse strandMUC6MUC2: 1,074,875–1,110,511, forward strandMUC2MUC5AC: 1,157,953–1,201,138, forward strandMUC5ACMUC5B: 1,223,066–1,262,172, forward strandMUC5BTOLLIP: 1,264,771–1,310,258, reverse strandTOLLIPDiagram of SLC25A22: 10 exons on the reverse strand of chromosome 11Exon 9: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 10: 790,475–792,068, 1,594 basesExon 9: 792,142–792,217, 76 basesExon 8: 792,304–792,458, 155 basesExon 7: 792,553–792,727, 175 basesExon 6: 792,870–792,988, 119 basesExon 5: 793,529–793,619, 91 basesExon 4: 794,458–794,513, 56 basesExon 3: 794,776–794,901, 126 basesExon 2: 794,987–795,169, 183 basesExon 1: 798,217–798,281, 65 bases109876543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.6 kb of the gene's 7.8 kb; 972 of those bases code for the protein.

    How a genome test reads SLC25A22

    18

    positions in SLC25A22 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 7.8 kb of SLC25A22, introns included, not only the 2.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SLC25A22 gene: solute carrier family 25 member 22. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc25a22

    Vancouver

    Dante Labs. SLC25A22 gene: solute carrier family 25 member 22 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc25a22

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