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Gene

UBE3C

ubiquitin protein ligase E3C

Summary

Cytogenetic location
7q36.3
Coordinates
Chromosome 7: 157,138,926–157,269,370 (GRCh38)
Exons
23 exons across 130.4 kb
Protein
1,083 amino acids
Also known as
KIAA0010, KIAA10
MANE Select transcript
ENST00000348165.10NM_014671.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads UBE3C yet. The test sequences your whole genome, so your data includes it all the same.

How UBE3C is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where UBE3C sits. UBE3C and 5 genes near it on chromosome 7, from 156,704,148 to 157,704,147.Chromosome 77q36.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3156.8 Mb157 Mb157.2 Mb157.4 Mb157.6 MbLMBR1: 156,668,946–156,893,225, reverse strandLMBR1NOM1: 156,949,706–156,973,176, forward strandNOM1MNX1: 156,993,901–157,010,668, reverse strandMNX1UBE3C: 157,138,926–157,269,370, forward strandUBE3CDNAJB6: 157,335,381–157,432,974, forward strandDNAJB6PTPRN2: 157,539,056–158,587,841, reverse strandPTPRN2Diagram of UBE3C: 23 exons on the forward strand of chromosome 7Exon 15: 1 known disease-causing siteExon 1: 157,138,926–157,139,338, 413 basesExon 2: 157,163,810–157,163,863, 54 basesExon 3: 157,169,048–157,169,122, 75 basesExon 4: 157,170,304–157,170,450, 147 basesExon 5: 157,174,919–157,175,034, 116 basesExon 6: 157,178,690–157,178,847, 158 basesExon 7: 157,181,518–157,181,671, 154 basesExon 8: 157,182,108–157,182,328, 221 basesExon 9: 157,183,878–157,184,029, 152 basesExon 10: 157,186,834–157,187,021, 188 basesExon 11: 157,201,721–157,201,807, 87 basesExon 12: 157,207,398–157,207,555, 158 basesExon 13: 157,207,703–157,207,935, 233 basesExon 14: 157,216,867–157,216,971, 105 basesExon 15: 157,220,689–157,220,776, 88 basesExon 16: 157,223,254–157,223,351, 98 basesExon 17: 157,225,407–157,225,539, 133 basesExon 18: 157,231,080–157,231,327, 248 basesExon 19: 157,248,368–157,248,580, 213 basesExon 20: 157,253,954–157,254,142, 189 basesExon 21: 157,254,244–157,254,310, 67 basesExon 22: 157,256,914–157,257,044, 131 basesExon 23: 157,267,585–157,269,370, 1,786 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.2 kb of the gene's 130.4 kb; 3,252 of those bases code for the protein.

How a genome test reads UBE3C

1

position in UBE3C where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 130.4 kb of UBE3C, introns included, not only the 5.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UBE3C gene: ubiquitin protein ligase E3C. Retrieved 17 October 2026, from https://dantelabs.com/genes/ube3c

Vancouver

Dante Labs. UBE3C gene: ubiquitin protein ligase E3C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ube3c

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