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Gene

SCN1B

sodium voltage-gated channel beta subunit 1

Summary

Cytogenetic location
19q13.11
Coordinates
Chromosome 19: 35,030,470–35,040,449 (GRCh38)
Exons
6 exons across 10 kb
Protein
218 amino acids
MANE Select transcript
ENST00000262631.11NM_001037.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    How SCN1B is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Variants with a page
    Chromosome 19, with a bracket where SCN1B sits. SCN1B and 28 genes near it on chromosome 19, from 34,535,460 to 35,535,459.Chromosome 1919q13.11p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4334.6 Mb34.8 Mb35 Mb35.2 Mb35.4 MbSCGB2B2: 34,590,644–34,677,159, reverse strandSCGB2B2ZNF302: 34,677,084–34,687,065, forward strandZNF302ZNF181: 34,734,155–34,750,437, forward strandZNF181ZNF599: 34,758,073–34,773,253, reverse strandZNF599ZNF30: 34,926,887–34,945,172, forward strandZNF30ZNF792: 34,956,167–34,964,293, reverse strandZNF792GRAMD1A: 34,994,537–35,027,406, forward strandGRAMD1ASCN1B: 35,030,470–35,040,449, forward strandSCN1BHPN: 35,040,506–35,066,592, forward strandHPN: 35,106,510–35,124,297, forward strandFXYD3: 35,115,521–35,125,653, forward strandFXYD3LGI4: 35,124,507–35,142,451, reverse strandLGI4FXYD1: 35,133,987–35,143,109, forward strandFXYD1FXYD7: 35,143,148–35,154,303, forward strandFXYD5: 35,154,440–35,171,796, forward strandFAM187B: 35,224,800–35,228,739, reverse strandFAM187BLSR: 35,248,330–35,267,967, forward strandLSRUSF2: 35,268,485–35,279,821, forward strandUSF2HAMP: 35,280,716–35,285,146, forward strandHAMPMAG: 35,291,647–35,316,932, forward strandMAGCD22: 35,319,261–35,347,361, forward strandCD22FFAR1: 35,347,902–35,353,864, forward strandFFAR1FFAR3: 35,358,348–35,360,489, forward strandFFAR3GPR42: 35,371,068–35,372,962, forward strandGPR42FFAR2: 35,443,907–35,451,767, forward strandFFAR2KRTDAP: 35,487,324–35,495,558, reverse strandKRTDAPDMKN: 35,497,220–35,513,704, reverse strandDMKNSBSN: 35,523,367–35,528,351, reverse strandSBSNGAPDHS: 35,533,455–35,545,319, forward strandGAPDHSDiagram of SCN1B: 6 exons on the forward strand of chromosome 19Exon 1: 6 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 3: 13 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 1: 35,030,470–35,030,860, 391 basesExon 2: 35,032,528–35,032,694, 167 basesExon 3: 35,033,499–35,033,739, 241 basesExon 4: 35,039,117–35,039,258, 142 basesExon 5: 35,039,635–35,039,706, 72 basesExon 6: 35,039,797–35,040,449, 653 bases1234565′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 1.7 kb of the gene's 10 kb; 657 of those bases code for the protein.

    How a genome test reads SCN1B

    38

    positions in SCN1B where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 10 kb of SCN1B, introns included, not only the 1.7 kb of exons.

    Variants with a page (1)

    The SCN1B variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

    VariantExon or intronPosition (GRCh38)ClinVar classificationReview status
    c.449-2A>GIntron 335,039,115Pathogenic3 stars out of 4 reviewed by expert panel

    Genes linked to the same conditions

    Traits linked to SCN1B

    The Human Phenotype Ontology lists these as features of the rare conditions SCN1B can cause. Each trait's page lists the other genes linked to it.

    Abnormality of the nervous system

    Show 66 more traits

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SCN1B gene: sodium voltage-gated channel beta subunit 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/scn1b

    Vancouver

    Dante Labs. SCN1B gene: sodium voltage-gated channel beta subunit 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/scn1b

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