Skip to content
Use your HSA or FSA funds

Gene

CUL3

cullin 3

Summary

Cytogenetic location
2q36.2
Coordinates
Chromosome 2: 224,470,150–224,585,363 (GRCh38)
Exons
16 exons across 115.2 kb
Protein
768 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000264414.9NM_003590.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Monogenic Hypertension & Mineralocorticoid Disorders

    • Pseudohypoaldosteronism Type 2 (Gordon Syndrome)Autosomal dominant

      A condition caused by changes in WNK1, WNK4, KLHL3 or CUL3 that causes high blood pressure with high potassium and acid build-up in the blood.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it points to thiazide diuretics, which usually correct both the blood pressure and the potassium.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How CUL3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where CUL3 sits. CUL3 and 4 genes near it on chromosome 2, from 224,027,757 to 225,027,756.Chromosome 22q36.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3224.2 Mb224.4 Mb224.6 Mb224.8 Mb225 MbSERPINE2: 223,975,045–224,039,688, reverse strandSERPINE2FAM124B: 224,376,339–224,402,113, reverse strandFAM124BCUL3: 224,470,150–224,585,363, reverse strandCUL3CCDC195: 224,703,764–224,742,270, reverse strandCCDC195DOCK10: 224,765,090–225,042,724, reverse strandDOCK10Diagram of CUL3: 16 exons on the reverse strand of chromosome 2Exon 16: 1 known disease-causing siteExon 14: 6 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 10: 4 known disease-causing sitesExon 9: 8 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 6 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 16: 224,470,150–224,474,376, 4,227 basesExon 15: 224,478,200–224,478,345, 146 basesExon 14: 224,481,892–224,482,078, 187 basesExon 13: 224,495,832–224,495,966, 135 basesExon 12: 224,497,753–224,497,849, 97 basesExon 11: 224,500,363–224,500,487, 125 basesExon 10: 224,502,965–224,503,072, 108 basesExon 9: 224,503,652–224,503,822, 171 basesExon 8: 224,505,956–224,506,132, 177 basesExon 7: 224,506,858–224,507,003, 146 basesExon 6: 224,511,354–224,511,582, 229 basesExon 5: 224,513,524–224,513,638, 115 basesExon 4: 224,514,612–224,514,772, 161 basesExon 3: 224,535,528–224,535,641, 114 basesExon 2: 224,557,659–224,557,856, 198 basesExon 1: 224,584,944–224,585,363, 420 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 115.2 kb; 2,307 of those bases code for the protein.

How a genome test reads CUL3

54

positions in CUL3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 115.2 kb of CUL3, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CUL3 gene: cullin 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/cul3

Vancouver

Dante Labs. CUL3 gene: cullin 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cul3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test