Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

DYRK1A

dual specificity tyrosine phosphorylation regulated kinase 1A

Summary

Cytogenetic location
21q22.13
Coordinates
Chromosome 21: 37,366,773–37,526,358 (GRCh38)
Exons
12 exons across 159.6 kb
Protein
754 amino acids
Previous symbols
DYRK1, DYRK, MNBH
MANE Select transcript
ENST00000647188.2NM_001347721.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    How DYRK1A is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 21, with a bracket where DYRK1A sits. DYRK1A and 6 genes near it on chromosome 21, from 36,946,566 to 37,946,565.Chromosome 2121q22.13p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.337 Mb37.2 Mb37.4 Mb37.6 Mb37.8 MbHLCS: 36,748,626–36,990,236, reverse strandHLCSRIPPLY3: 37,006,150–37,019,662, forward strandRIPPLY3PIGP: 37,036,533–37,073,820, reverse strandPIGPTTC3: 37,073,206–37,203,112, forward strandTTC3VPS26C: 37,221,749–37,268,104, reverse strandVPS26CDYRK1A: 37,366,773–37,526,358, forward strandDYRK1AKCNJ6: 37,607,373–38,121,345, reverse strandKCNJ6Diagram of DYRK1A: 12 exons on the forward strand of chromosome 21Exon 3: 3 known disease-causing sitesExon 4: 9 known disease-causing sitesExon 5: 18 known disease-causing sitesExon 6: 14 known disease-causing sitesExon 7: 30 known disease-causing sitesExon 8: 20 known disease-causing sitesExon 9: 12 known disease-causing sitesExon 10: 18 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 12: 9 known disease-causing sitesExon 1: 37,366,773–37,367,628, 856 basesExon 2: 37,420,299–37,420,384, 86 basesExon 3: 37,472,684–37,472,880, 197 basesExon 4: 37,478,208–37,478,300, 93 basesExon 5: 37,480,638–37,480,826, 189 basesExon 6: 37,486,467–37,486,614, 148 basesExon 7: 37,490,175–37,490,461, 287 basesExon 8: 37,493,017–37,493,163, 147 basesExon 9: 37,496,118–37,496,258, 141 basesExon 10: 37,505,283–37,505,589, 307 basesExon 11: 37,506,099–37,506,223, 125 basesExon 12: 37,511,911–37,526,358, 14,448 bases1246810125′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 17 kb of the gene's 159.6 kb; 2,265 of those bases code for the protein.

    How a genome test reads DYRK1A

    158

    positions in DYRK1A where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 159.6 kb of DYRK1A, introns included, not only the 17 kb of exons.

    Genes linked to the same conditions

    Traits linked to DYRK1A

    The Human Phenotype Ontology lists these as features of the rare conditions DYRK1A can cause. Each trait's page lists the other genes linked to it.

    Abnormality of the nervous system

    Show 35 more traits

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). DYRK1A gene: dual specificity tyrosine phosphorylation regulated kinase 1A. Retrieved 17 October 2026, from https://dantelabs.com/genes/dyrk1a

    Vancouver

    Dante Labs. DYRK1A gene: dual specificity tyrosine phosphorylation regulated kinase 1A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dyrk1a

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test