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Gene

PRODH

proline dehydrogenase 1

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 18,912,781–18,936,293 (GRCh38)
Exons
14 exons across 23.5 kb
Protein
600 amino acids
Also known as
HSPOX2, PRODH1, PIG6, PRODH2, TP53I6, POX
MANE Select transcript
ENST00000357068.11NM_016335.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PRODH yet. The test sequences your whole genome, so your data includes it all the same.

How PRODH is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where PRODH sits. PRODH and 15 genes near it on chromosome 22, from 18,424,537 to 19,424,536.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3318.6 Mb18.8 Mb19 Mb19.2 Mb19.4 MbGGTLC3: 18,516,338–18,518,161, reverse strandGGTLC3TMEM191B: 18,527,802–18,530,573, forward strandTMEM191BRIMBP3: 18,605,815–18,611,919, reverse strandRIMBP3FAM246B: 18,633,984–18,634,682, forward strandFAM246BDGCR6: 18,905,677–18,916,623, forward strandDGCR6: 18,906,238–18,947,732, forward strandPRODH: 18,912,781–18,936,293, reverse strandPRODHFAM246C: 19,029,524–19,031,242, forward strandFAM246CDGCR2: 19,036,280–19,122,461, reverse strandDGCR2ESS2: 19,130,279–19,144,684, reverse strandESS2TSSK2: 19,131,308–19,132,622, forward strandTSSK2GSC2: 19,146,993–19,150,292, reverse strandGSC2SLC25A1: 19,175,573–19,178,863, reverse strandSLC25A1CLTCL1: 19,179,319–19,291,774, reverse strandCLTCL1HIRA: 19,330,185–19,447,450, reverse strandHIRAC22orf39: 19,351,368–19,447,714, reverse strandC22orf39Diagram of PRODH: 14 exons on the reverse strand of chromosome 22Exon 13: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 1: 6 known disease-causing sitesExon 14: 18,912,781–18,913,362, 582 basesExon 13: 18,913,438–18,913,526, 89 basesExon 12: 18,916,890–18,916,988, 99 basesExon 11: 18,918,316–18,918,491, 176 basesExon 10: 18,919,451–18,919,597, 147 basesExon 9: 18,919,706–18,919,798, 93 basesExon 8: 18,921,342–18,921,423, 82 basesExon 7: 18,922,325–18,922,404, 80 basesExon 6: 18,922,817–18,922,933, 117 basesExon 5: 18,923,115–18,923,179, 65 basesExon 4: 18,925,051–18,925,200, 150 basesExon 3: 18,925,688–18,925,722, 35 basesExon 2: 18,930,990–18,931,198, 209 basesExon 1: 18,936,015–18,936,293, 279 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 23.5 kb; 1,803 of those bases code for the protein.

How a genome test reads PRODH

22

positions in PRODH where ClinVar classes a change as pathogenic or likely pathogenic

22 of them (100%) fall in regions short reads find hard.

  • Low mappability (22 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (22 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 23.5 kb of PRODH, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRODH gene: proline dehydrogenase 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/prodh

Vancouver

Dante Labs. PRODH gene: proline dehydrogenase 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prodh

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