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Gene

GNB5

G protein subunit beta 5

Summary

Cytogenetic location
15q21.2
Coordinates
Chromosome 15: 52,115,100–52,191,392 (GRCh38)
Exons
13 exons across 76.3 kb
Protein
395 amino acids
Also known as
GB5
MANE Select transcript
ENST00000261837.12NM_016194.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads GNB5 yet. The test sequences your whole genome, so your data includes it all the same.

How GNB5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where GNB5 sits. GNB5 and 12 genes near it on chromosome 15, from 51,653,246 to 52,653,245.Chromosome 1515q21.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.351.8 Mb52 Mb52.2 Mb52.4 Mb52.6 MbSCG3: 51,681,439–51,721,026, forward strandSCG3LYSMD2: 51,722,646–51,751,585, reverse strandLYSMD2TMOD2: 51,751,564–51,816,363, forward strandTMOD2TMOD3: 51,829,626–51,947,295, forward strandTMOD3LEO1: 51,937,788–51,971,922, reverse strandLEO1MAPK6: 51,952,106–52,067,375, forward strandMAPK6: 52,045,846–52,045,899, forward strandBCL2L10: 52,109,263–52,112,775, reverse strandBCL2L10GNB5: 52,115,100–52,191,392, reverse strandGNB5MYO5C: 52,192,309–52,295,815, reverse strandMYO5CMYO5A: 52,307,281–52,529,248, reverse strandMYO5AARPP19: 52,547,045–52,569,883, reverse strandARPP19ATOSA: 52,581,317–52,709,824, reverse strandATOSADiagram of GNB5: 13 exons on the reverse strand of chromosome 15Exon 12: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 13: 52,115,100–52,122,768, 7,669 basesExon 12: 52,124,473–52,124,639, 167 basesExon 11: 52,125,948–52,126,044, 97 basesExon 10: 52,128,196–52,128,244, 49 basesExon 9: 52,133,378–52,133,469, 92 basesExon 8: 52,135,613–52,135,756, 144 basesExon 7: 52,141,140–52,141,272, 133 basesExon 6: 52,147,459–52,147,535, 77 basesExon 5: 52,149,884–52,149,925, 42 basesExon 4: 52,153,940–52,154,076, 137 basesExon 3: 52,179,768–52,179,879, 112 basesExon 2: 52,184,551–52,184,694, 144 basesExon 1: 52,191,322–52,191,392, 71 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.9 kb of the gene's 76.3 kb; 1,188 of those bases code for the protein.

How a genome test reads GNB5

12

positions in GNB5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 76.3 kb of GNB5, introns included, not only the 8.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GNB5 gene: G protein subunit beta 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/gnb5

Vancouver

Dante Labs. GNB5 gene: G protein subunit beta 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gnb5

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