Gene
GRM7
glutamate metabotropic receptor 7
- HGNC 4599↗(opens in a new tab)
- Ensembl gene ENSG00000196277↗(opens in a new tab)
- NCBI Gene 2917↗(opens in a new tab)
Summary
- Cytogenetic location
- 3p26.1
- Coordinates
- Chromosome 3: 6,861,115–7,741,533 (GRCh38)
- Exons
- 10 exons across 880.4 kb
- Protein
- 915 amino acids
- Also known as
- GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87
- MANE Select transcript
- ENST00000357716.9NM_000844.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads GRM7 yet. The test sequences your whole genome, so your data includes it all the same.
How GRM7 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.1 kb of the gene's 880.4 kb; 2,748 of those bases code for the protein.
How a genome test reads GRM7
4
positions in GRM7 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 880.4 kb of GRM7, introns included, not only the 4.1 kb of exons.
Traits linked to GRM7
The Human Phenotype Ontology lists these as features of the rare conditions GRM7 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Elevated brain choline level by MRS
- Epilepsy
- Intellectual disability
- Reduced brain N-acetyl aspartate level by MRS
- Severe global developmental delay
- CNS hypomyelination
- Degeneration of cerebrum
- Epileptic encephalopathy
Show 40 more traits
- Focal motor seizure
- Generalized myoclonic seizure
- Global developmental delay
- Interictal epileptiform activity
- Underdevelopment of part of brain called corpus callosum
- Degeneration of cerebellum
- Difficulty sleeping
- EEG abnormality
- EEG with burst suppression
- Focal tonic seizure
- Hypsarrhythmia
- Increased reflexes
- Lethargy
- Repeated seizures without recovery between them
- Autism spectrum disorder
- Brief seizures with staring spells
- Choreoathetosis
- Delayed myelination
- Diffuse cerebral atrophy
- Diffuse white matter abnormalities
- Disorder of involuntary muscle movements
- EEG with spike-wave complexes
- Episodic ataxia
- Febrile seizure (within the age range of 3 months to 6 years)
- Fewer and broader ridges in brain
- Generalized clonic seizure
- Generalized tonic seizure
- Grand mal seizures
- Hippocampal atrophy
- Infantile spasms
- Jerking
- Loss of developmental milestones
- More active than typical
- Seizure affecting one half of brain
- Self-injurious behavior
- Self-mutilation
- Sudden loss of muscle tone
- Tremor
- Uni- and bilateral multifocal epileptiform discharges
- Dystonia
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). GRM7 gene: glutamate metabotropic receptor 7. Retrieved 17 October 2026, from https://dantelabs.com/genes/grm7
Dante Labs. GRM7 gene: glutamate metabotropic receptor 7 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/grm7
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