Gene
MAPK10
mitogen-activated protein kinase 10
- HGNC 6872↗(opens in a new tab)
- Ensembl gene ENSG00000109339↗(opens in a new tab)
- NCBI Gene 5602↗(opens in a new tab)
Summary
- Cytogenetic location
- 4q21.3
- Coordinates
- Chromosome 4: 86,010,405–86,360,053 (GRCh38)
- Exons
- 14 exons across 349.6 kb
- Protein
- 464 amino acids
- Also known as
- JNK3, p493F12, p54bSAPK
- Previous symbols
- PRKM10
- MANE Select transcript
- ENST00000641462.2NM_138982.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How MAPK10 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 8.7 kb of the gene's 349.6 kb; 1,395 of those bases code for the protein.
Traits linked to MAPK10
The Human Phenotype Ontology lists these as features of the rare conditions MAPK10 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- EEG with focal sharp slow waves
- Encephalopathy
- Intellectual disability
- Abnormal shape of brainstem
- Aggressive behavior
- Atypical absence seizure
- Autism spectrum disorder
- Behavioral abnormality
Show 16 more traits
- EEG abnormality
- Falls
- Generalized tonic seizure
- Grand mal seizures
- Irritability
- Jerking
- Mental deterioration
- More active than typical
- Neurodevelopmental delay
- Personality disorder
- Sudden loss of muscle tone
- Generalized myoclonic seizure
- Lack of feeling, emotion, interest
- Loss of developmental milestones
- Psychosis
- Seizure affecting one half of brain
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). MAPK10 gene: mitogen-activated protein kinase 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/mapk10
Dante Labs. MAPK10 gene: mitogen-activated protein kinase 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mapk10
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