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Gene

HAL

histidine ammonia-lyase

Summary

Cytogenetic location
12q23.1
Coordinates
Chromosome 12: 95,972,662–95,996,344 (GRCh38)
Exons
21 exons across 23.7 kb
Protein
657 amino acids
Previous symbols
HIS
MANE Select transcript
ENST00000261208.8NM_002108.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HAL yet. The test sequences your whole genome, so your data includes it all the same.

How HAL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where HAL sits. HAL and 9 genes near it on chromosome 12, from 95,484,503 to 96,484,502.Chromosome 1212q23.1p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3395.6 Mb95.8 Mb96 Mb96.2 Mb96.4 MbMETAP2: 95,473,520–95,515,935, forward strandMETAP2USP44: 95,515,926–95,553,341, reverse strandUSP44NTN4: 95,657,529–95,791,373, reverse strandNTN4SNRPF: 95,858,762–95,903,828, forward strandSNRPFCCDC38: 95,867,048–95,942,680, reverse strandCCDC38AMDHD1: 95,943,046–95,968,830, forward strandAMDHD1HAL: 95,972,662–95,996,344, reverse strandHALLTA4H: 96,000,298–96,043,523, reverse strandLTA4HELK3: 96,193,978–96,269,835, forward strandELK3CDK17: 96,278,227–96,400,597, reverse strandCDK17Diagram of HAL: 21 exons on the reverse strand of chromosome 12Exon 18: 1 known disease-causing siteExon 21: 95,972,662–95,974,372, 1,711 basesExon 20: 95,976,429–95,976,498, 70 basesExon 19: 95,976,598–95,976,706, 109 basesExon 18: 95,977,944–95,978,078, 135 basesExon 17: 95,980,556–95,980,721, 166 basesExon 16: 95,980,798–95,980,863, 66 basesExon 15: 95,983,911–95,983,991, 81 basesExon 14: 95,985,908–95,985,966, 59 basesExon 13: 95,986,065–95,986,160, 96 basesExon 12: 95,987,067–95,987,214, 148 basesExon 11: 95,988,193–95,988,240, 48 basesExon 10: 95,990,393–95,990,532, 140 basesExon 9: 95,992,680–95,992,805, 126 basesExon 8: 95,993,451–95,993,488, 38 basesExon 7: 95,993,772–95,993,838, 67 basesExon 6: 95,993,926–95,993,998, 73 basesExon 5: 95,994,090–95,994,164, 75 basesExon 4: 95,994,798–95,994,825, 28 basesExon 3: 95,994,933–95,994,993, 61 basesExon 2: 95,995,664–95,995,991, 328 basesExon 1: 95,996,078–95,996,344, 267 bases21201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 23.7 kb; 1,974 of those bases code for the protein.

How a genome test reads HAL

1

position in HAL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.7 kb of HAL, introns included, not only the 3.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HAL gene: histidine ammonia-lyase. Retrieved 16 October 2026, from https://dantelabs.com/genes/hal

Vancouver

Dante Labs. HAL gene: histidine ammonia-lyase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hal

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