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Gene

ALDH5A1

aldehyde dehydrogenase 5 family member A1

Summary

Cytogenetic location
6p22.3
Coordinates
Chromosome 6: 24,494,969–24,537,207 (GRCh38)
Exons
10 exons across 42.2 kb
Protein
535 amino acids
Also known as
SSADH, SSDH
MANE Select transcript
ENST00000357578.8NM_001080.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ALDH5A1 yet. The test sequences your whole genome, so your data includes it all the same.

How ALDH5A1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where ALDH5A1 sits. ALDH5A1 and 12 genes near it on chromosome 6, from 24,016,088 to 25,016,087.Chromosome 66p22.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2724.2 Mb24.4 Mb24.6 Mb24.8 Mb25 MbNRSN1: 24,126,154–24,154,900, forward strandNRSN1DCDC2: 24,171,747–24,383,300, reverse strandDCDC2MRS2: 24,402,796–24,431,065, forward strandMRS2GPLD1: 24,418,076–24,495,205, reverse strandGPLD1ALDH5A1: 24,494,969–24,537,207, forward strandALDH5A1KIAA0319: 24,544,104–24,646,197, reverse strandKIAA0319TDP2: 24,649,917–24,667,052, reverse strandTDP2ACOT13: 24,666,901–24,714,084, forward strandACOT13C6orf62: 24,704,105–24,720,900, reverse strandC6orf62GMNN: 24,774,892–24,788,205, forward strandGMNNARMH2: 24,797,323–24,798,917, reverse strandARMH2: 24,797,373–24,809,798, reverse strandRIPOR2: 24,803,362–25,042,170, reverse strandRIPOR2Diagram of ALDH5A1: 10 exons on the forward strand of chromosome 6Exon 1: 24 known disease-causing sitesExon 2: 13 known disease-causing sitesExon 3: 14 known disease-causing sitesExon 4: 17 known disease-causing sitesExon 5: 13 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 11 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 15 known disease-causing sitesExon 1: 24,494,969–24,495,350, 382 basesExon 2: 24,502,523–24,502,606, 84 basesExon 3: 24,503,263–24,503,433, 171 basesExon 4: 24,504,869–24,504,985, 117 basesExon 5: 24,515,167–24,515,310, 144 basesExon 6: 24,520,401–24,520,544, 144 basesExon 7: 24,522,767–24,522,925, 159 basesExon 8: 24,527,997–24,528,166, 170 basesExon 9: 24,532,119–24,532,177, 59 basesExon 10: 24,533,507–24,537,207, 3,701 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 42.2 kb; 1,608 of those bases code for the protein.

How a genome test reads ALDH5A1

130

positions in ALDH5A1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 42.2 kb of ALDH5A1, introns included, not only the 5.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALDH5A1 gene: aldehyde dehydrogenase 5 family member A1. Retrieved 17 October 2026, from https://dantelabs.com/genes/aldh5a1

Vancouver

Dante Labs. ALDH5A1 gene: aldehyde dehydrogenase 5 family member A1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/aldh5a1

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