Skip to content
Use your HSA or FSA funds

Gene

ALG14

ALG14 UDP-N-acetylglucosaminyltransferase subunit

Summary

Cytogenetic location
1p21.3
Coordinates
Chromosome 1: 94,974,405–95,072,951 (GRCh38)
Exons
4 exons across 98.5 kb
Protein
216 amino acids
Also known as
MGC19780
MANE Select transcript
ENST00000370205.6NM_144988.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Myasthenic Syndrome

    • Congenital Myasthenic Syndrome (All Types)

      Umbrella term covering all congenital myasthenic syndromes, including the common CHRNE, RAPSN, DOK7 and MUSK forms.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Many forms respond to specific medications such as pyridostigmine, salbutamol or ephedrine, and the right choice depends on the gene involved.

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 2 GenCC submitters rate it definitive or strong

How ALG14 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where ALG14 sits. ALG14 and 6 genes near it on chromosome 1, from 94,523,678 to 95,523,677.Chromosome 11p21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4494.6 Mb94.8 Mb95 Mb95.2 Mb95.4 MbF3: 94,528,263–94,541,851, reverse strandF3SLC44A3: 94,820,278–94,895,246, forward strandSLC44A3CNN3: 94,896,949–94,927,749, reverse strandCNN3ALG14: 94,974,405–95,072,951, reverse strandALG14TLCD4: 95,096,670–95,197,607, forward strandTLCD4TLCD4-RWDD3: 95,117,923–95,247,225, forward strandTLCD4-RWDD3RWDD3: 95,234,067–95,247,691, forward strandRWDD3Diagram of ALG14: 4 exons on the reverse strand of chromosome 1Exon 2: 1 known disease-causing siteExon 4: 94,974,405–94,983,306, 8,902 basesExon 3: 95,027,129–95,027,260, 132 basesExon 2: 95,064,866–95,065,017, 152 basesExon 1: 95,072,763–95,072,951, 189 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.4 kb of the gene's 98.5 kb; 651 of those bases code for the protein.

How a genome test reads ALG14

2

positions in ALG14 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 98.5 kb of ALG14, introns included, not only the 9.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALG14 gene: ALG14 UDP-N-acetylglucosaminyltransferase subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/alg14

Vancouver

Dante Labs. ALG14 gene: ALG14 UDP-N-acetylglucosaminyltransferase subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alg14

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test