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Gene

GNAO1

G protein subunit alpha o1

Summary

Cytogenetic location
16q13
Coordinates
Chromosome 16: 56,191,489–56,357,444 (GRCh38)
Exons
9 exons across 166 kb
Protein
354 amino acids
Also known as
G-ALPHA-o
MANE Select transcript
ENST00000262493.12NM_020988.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How GNAO1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where GNAO1 sits. GNAO1 and 19 genes near it on chromosome 16, from 55,774,467 to 56,774,466.Chromosome 1616q13p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.355.8 Mb56 Mb56.2 Mb56.4 Mb56.6 MbCES1: 55,802,845–55,833,337, reverse strandCES1CES5A: 55,846,154–55,956,031, reverse strandCES5AGNAO1: 56,191,489–56,357,444, forward strandGNAO1AMFR: 56,361,449–56,425,598, reverse strandAMFRNUDT21: 56,428,473–56,452,199, reverse strandNUDT21: 56,430,556–56,501,497, reverse strandOGFOD1: 56,451,508–56,479,122, forward strandOGFOD1BBS2: 56,465,640–56,582,667, reverse strandBBS2MT4: 56,565,073–56,569,108, forward strandMT4MT3: 56,589,074–56,591,093, forward strandMT3MT2A: 56,608,130–56,609,503, forward strandMT2AMT1E: 56,625,475–56,627,112, forward strandMT1EMT1M: 56,632,485–56,633,986, forward strandMT1MMT1A: 56,638,202–56,640,087, forward strandMT1AMT1B: 56,651,885–56,653,204, forward strandMT1F: 56,657,640–56,660,698, forward strandMT1G: 56,666,730–56,668,072, reverse strandMT1H: 56,669,660–56,671,135, forward strandMT1HMT1X: 56,682,058–56,686,110, forward strandMT1XNUP93: 56,730,095–56,850,286, forward strandNUP93Diagram of GNAO1: 9 exons on the forward strand of chromosome 16Exon 1: 6 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 6: 10 known disease-causing sitesExon 7: 10 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 1: 56,191,489–56,192,353, 865 basesExon 2: 56,192,574–56,192,616, 43 basesExon 3: 56,275,931–56,276,072, 142 basesExon 4: 56,328,631–56,328,791, 161 basesExon 5: 56,334,729–56,334,857, 129 basesExon 6: 56,336,731–56,336,860, 130 basesExon 7: 56,351,384–56,351,537, 154 basesExon 8: 56,354,866–56,355,081, 216 basesExon 9: 56,356,103–56,357,444, 1,342 bases1595′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.2 kb of the gene's 166 kb; 1,065 of those bases code for the protein.

    How a genome test reads GNAO1

    41

    positions in GNAO1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 166 kb of GNAO1, introns included, not only the 3.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GNAO1 gene: G protein subunit alpha o1. Retrieved 17 October 2026, from https://dantelabs.com/genes/gnao1

    Vancouver

    Dante Labs. GNAO1 gene: G protein subunit alpha o1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gnao1

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