Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

DNAJC21

DnaJ heat shock protein family (Hsp40) member C21

Summary

Cytogenetic location
5p13.2
Coordinates
Chromosome 5: 34,929,559–34,958,964 (GRCh38)
Exons
12 exons across 29.4 kb
Protein
531 amino acids
Also known as
GS3, DNAJA5, JJJ1
MANE Select transcript
ENST00000648817.1NM_001012339.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Rare Inherited Bone Marrow Failure Syndromes

    • Bone Marrow Failure Syndrome

      A group of rare conditions linked to genes such as DNAJC21, MYSM1 and SRP72, and to combined ADH5 and ALDH2 deficiency (AMED syndrome), causing low blood counts, sometimes with developmental or other features.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A diagnosis informs the choice of related stem cell donors and transplant preparation, and supports monitoring for myelodysplastic syndrome and leukaemia.

How DNAJC21 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where DNAJC21 sits. DNAJC21 and 6 genes near it on chromosome 5, from 34,444,262 to 35,444,261.Chromosome 55p13.2p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.334.6 Mb34.8 Mb35 Mb35.2 Mb35.4 MbRAI14: 34,655,566–34,832,613, forward strandRAI14TTC23L: 34,838,833–34,903,125, forward strandTTC23LRAD1: 34,894,176–34,930,394, reverse strandRAD1BRIX1: 34,915,273–34,926,622, forward strandBRIX1DNAJC21: 34,929,559–34,958,964, forward strandDNAJC21AGXT2: 34,997,427–35,048,240, reverse strandAGXT2PRLR: 35,048,756–35,230,678, reverse strandPRLRDiagram of DNAJC21: 12 exons on the forward strand of chromosome 5Exon 1: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 1: 34,929,559–34,929,916, 358 basesExon 2: 34,933,815–34,933,908, 94 basesExon 3: 34,935,710–34,935,833, 124 basesExon 4: 34,936,144–34,936,266, 123 basesExon 5: 34,937,326–34,937,630, 305 basesExon 6: 34,938,858–34,939,009, 152 basesExon 7: 34,941,096–34,941,183, 88 basesExon 8: 34,944,867–34,945,025, 159 basesExon 9: 34,945,761–34,945,803, 43 basesExon 10: 34,950,170–34,950,342, 173 basesExon 11: 34,953,926–34,954,001, 76 basesExon 12: 34,954,553–34,958,964, 4,412 bases1246810125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.1 kb of the gene's 29.4 kb; 1,596 of those bases code for the protein.

How a genome test reads DNAJC21

13

positions in DNAJC21 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 29.4 kb of DNAJC21, introns included, not only the 6.1 kb of exons.

Genes linked to the same conditions

Traits linked to DNAJC21

The Human Phenotype Ontology lists these as features of the rare conditions DNAJC21 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAJC21 gene: DnaJ heat shock protein family (Hsp40) member C21. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnajc21

Vancouver

Dante Labs. DNAJC21 gene: DnaJ heat shock protein family (Hsp40) member C21 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnajc21

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test